Use of Diffusion Weighted Magnetic Resonance Imaging to Stage Gastric Adenocarcinoma Patients Preoperatively
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- efficacy of diffusion weighted magnetic resonance imaging to detect benign and malignant lymph nodes
研究概览
简要总结
Preoperative staging for gastric adenocarcinoma is an important procedure to detect advanced disease stateS for the patients in which the surgery may be unnecessary to perform. Although there are many imaging techniques for this purpose, sensitivity and specificity of these techniques still remains to be low.Preoperative detection of peritoneal carcinomatosis and involvement of lymph nodes beyond D2 may prevent surgical procedures.
Removal of the determined lymph nodes according to the type of the surgery is the accepted surgical method. However, accurate determination of malignant lymph nodes may prevent dissection of some groups of the lymph nodes. These findings may cause a new definition of gastric lymph node dissection.
详细描述
- proven endoscopic diagnosis of gastric adenocarcinoma
- for staging purposes, computed tomography for all patients
- evaluation of benign and malignant lymph nodes according to computed tomography findings and mapping of the lymph nodes
- to state precisely resectable patients according to computed tomography and anesthetic evaluation
- evaluation of benign and malignant lymph nodes according to diffusion weighted magnetic resonance imaging findings and mapping of the lymph nodes
- standard gastrectomy and D2 lymph node dissection
- mapping of the lymph nodes after taking the specimen out
- histopathological diagnosis of the lymph nodes and mapping
- comparison of the results taken from computed tomography, diffusion weighted magnetic resonance imaging and histopathological analysis
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •gastric adenocarcinoma proven by endoscopic biopsy;
- •application of both computed tomography and diffusion weighted magnetic resonance imaging;
- •standard gastrectomy and a D2 lymph node dissection;
- •desire to attend the study protocol
排除标准
- •preoperative neoadjuvant therapy;
- •metastatic disease;
- •undesired reaction to attend the study protocol
研究组 & 干预措施
diffusion MRI
histopathology of lymph nodes diagnosed by diffusion weighted magnetic resonance imaging
干预措施: diffusion weighted magnetic resonance imaging (Procedure)
结局指标
主要结局
efficacy of diffusion weighted magnetic resonance imaging to detect benign and malignant lymph nodes
时间窗: one year
to compare the radiologic diagnosis of benign and malignant lymph nodes with histopathological diagnosis
次要结局
未报告次要终点