Effects of Acute Partial Sleep Deprivation on Metabolic Health and Cognitive Function
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 48
- 主要终点
- Glycemic Control
研究概览
简要总结
This study will investigate whether various types of regular exercise can provide protective effects against metabolic abnormalities induced by sleep restriction. It will examine responses related to metabolic health, cognitive function, energy expenditure, subjective feelings, and human behaviors, including physical activity and energy intake.
详细描述
Sleep disturbances are common among the Taiwanese population due to work-related stress, shift work, and academic demands. Poor sleep can impair glucose and lipid metabolism, increasing the risk of cardiovascular disease and type 2 diabetes. This study will investigate whether regular exercise can mitigate these adverse effects. The findings aim to inform diverse exercise intervention strategies tailored to different populations to reduce health risks associated with insufficient sleep.
Participants will be healthy adults aged 20 to 45, categorized according to their habitual activity levels.
- Sedentary: fewer than 7,000 steps per day and no regular exercise in the past 6 months.
- Regular Aerobic Exercise: Running or cycling at least 2-3 times per week for the past 6 months.
- Regular Resistance Exercise: Resistance training performed at least 2-3 times per week for the past 6 months, with minimal aerobic training.
Eligible participants must have regular sleep habits (Pittsburgh Sleep Quality Index [PSQI] ≤ 5), stable body weight (±3% over the past 3 months), no chronic diseases, no smoking or drinking habits, and no special diets.
Prior to the first main trial, participants will complete assessments of V̇O2max and maximal muscle strength within 7 to 14 days before the main trials. They will also record one week of daily physical activity, sleep patterns (including bedtime and wake-up times), and diet (covering two weekdays and one weekend day) to ensure they meet the inclusion criteria.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age between 20-45 years.
- •Body Mass Index (BMI) between 18.5-27 kg/m².
- •No sleep-related medical conditions and good sleep quality, defined as a Pittsburgh Sleep Quality Index (PSQI) score ≤
- •Usual bedtime between 22:00-01:00, wake-up time between 06:00-09:00, with an average sleep duration of 7 to 9 hours; chronotype classified as "definitely not evening type" (score ≥ 42 on the Morningness-Eveningness Questionnaire), and no changes in sleep patterns over the past 3 months.
- •Without any metabolic or cardiovascular diseases, and not using medications that could affect metabolic responses.
- •No specific dietary habits, such as intermittent fasting or a ketogenic diet.
- •Maintaining a stable weight (no self-reported weight change ± 3 kg) for at least 3 months.
- •Resting blood pressure ≤ 130/80 mmHg.
- •No smoking or excessive alcohol consumption.
- •Not a shift worker.
- •No international travel across time zones has occurred within the past 3 months.
排除标准
- •Special diets (e.g., intermittent fasting, ketogenic diet)
- •Recent injuries or contraindications to intense exercise.
研究组 & 干预措施
Normal sleep
Participants will have an 8-hour sleep opportunity in the lab from 23:00 to 07:00.
干预措施: Normal sleep (Behavioral)
Partial sleep deprivation
Participants will have a 3-hour sleep opportunity in the lab from 03:00 to 07:00.
干预措施: Partial sleep deprivation (Behavioral)
结局指标
主要结局
Glycemic Control
时间窗: Baseline measurements and continuously at regular intervals throughout the 3-hour OGTT.
Glucose responses during the 3-hour oral glucose tolerance test (OGTT)
Pulse wave velocity (PWV)
时间窗: 0 (baseline), 60, 120 and 180 minutes during OGTT
Pulse wave velocity assessments (i.e., meters per second) will be collected before and during the 3-hour oral glucose tolerance test (OGTT).
Cognitive function (Accuracy)
时间窗: 0 (baseline), 90 and 180 minutes during OGTT
Accuracy (i.e., %) in computerized tests will be tested before and during the 3-hour oral glucose tolerance test (OGTT).
Cognitive function (Reaction time)
时间窗: 0 (baseline), 90 and 180 minutes during OGTT
Reaction time (i.e., milliseconds) in computerized tests will be tested before and during the 3-hour oral glucose tolerance test (OGTT).
次要结局
- Resting energy expenditure(0 (baseline), 60, 120 and 180 minutes during OGTT)
- Carbohydrate oxidation(0 (baseline), 60, 120 and 180 minutes during OGTT)
- Fat oxidation(0 (baseline), 60, 120 and 180 minutes during OGTT)
- Heart rate variability(0 (baseline), 60, 120 and 180 minutes during OGTT)
- Muscle oxygen saturation(0 minute (baseline) and throughout the entire 3-hour OGTT)
- Blood pressure(0 (baseline), 30, 60, 90, 120,150 and 180 minutes during OGTT)
研究者
Yung-Chih Chen
Principal Investigator
National Taiwan Normal University