Peri-operative Vitamin D Therapy for Hepatectomy

Not Applicable

Not yet recruiting

• Conditions: Hepatocellular Carcinoma; Vitamin D Deficiency; Perioperative Complication
• Interventions: Dietary Supplement: Placebo; Dietary Supplement: Vitamin D

• Registration Number: NCT05650151
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

The goal of this double-blind, randomized controlled trial is to test the effect of short-term and high-dose vitamin D therapy in patients undergoing hepatectomy for hepatocellular carcinoma.

Detailed Description

Participants will receive short-term high dose of vitamin D during perioperative period.

The main questions the study aims to answer are:

1. If vitamin D therapy benefits perioperative care

2. If short-term high dose of vitamin D supplement is safe

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Status Verified: 2022-11
• Study First Submitted: 2022-12-06
• Study First Submitted QC: 2022-12-06
• Last Update Submitted: 2022-12-06
• Study First Posted: 2022-12-14
• Last Update Posted: 2022-12-14
• Study Start: 2023-01-01
• Primary Completion: 2023-12-31
• Study Completion: 2024-01-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Patients older than 20 years
• Patients will undergo hepatectomy for hepatocellular carcinoma.

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Exclusion Criteria

• Patients with hypercalcemia, hyperparathyroidism, sarcoidosis, multiple myeloma

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	Placebo	-
Vitamin D group	Vitamin D	-

Primary Outcome Measures

Name	Time	Method
Infection rate	Perioperative period	Diagnosed by clinical presentation and relevant biomarker