Peri-operative Vitamin D Therapy for Hepatectomy
Not Applicable
Not yet recruiting
- Conditions
- Hepatocellular CarcinomaVitamin D DeficiencyPerioperative Complication
- Registration Number
- NCT05650151
- Lead Sponsor
- National Taiwan University Hospital
- Brief Summary
The goal of this double-blind, randomized controlled trial is to test the effect of short-term and high-dose vitamin D therapy in patients undergoing hepatectomy for hepatocellular carcinoma.
- Detailed Description
Participants will receive short-term high dose of vitamin D during perioperative period.
The main questions the study aims to answer are:
1. If vitamin D therapy benefits perioperative care
2. If short-term high dose of vitamin D supplement is safe
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
- Patients older than 20 years
- Patients will undergo hepatectomy for hepatocellular carcinoma.
Exclusion Criteria
- Patients with hypercalcemia, hyperparathyroidism, sarcoidosis, multiple myeloma
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Infection rate Perioperative period Diagnosed by clinical presentation and relevant biomarker
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie vitamin D's impact on hepatocellular carcinoma post-hepatectomy recovery?
How does peri-operative vitamin D supplementation compare to standard-of-care in reducing post-hepatectomy complications for HCC patients with vitamin D deficiency?
Which biomarkers correlate with improved outcomes in hepatocellular carcinoma patients receiving high-dose vitamin D therapy during hepatectomy?
What are the potential adverse events associated with high-dose vitamin D administration in the perioperative setting for HCC patients?
Are there synergistic effects when combining vitamin D therapy with other perioperative interventions in hepatocellular carcinoma hepatectomy patients?