Towards a High-fat Feeding Intervention Study: Identification of Markers for Inflammation and Organ Damage
- Conditions
- SepsisSystemic Inflammatory Response Syndrome
- Interventions
- Procedure: Blood collection
- Registration Number
- NCT00519350
- Lead Sponsor
- Maastricht University Medical Center
- Brief Summary
Patients undergoing major surgery, trauma or burns are prone to develop an exacerbated inflammatory response, which is potentially lethal to the individual. Recently, the researchers' group showed in a rodent model of hemorrhagic shock that high-fat feeding administered before shock attenuates inflammation and reduces intestinal and hepatic damage. In the mechanism that underlies this protective effect, the release of cholecystokinin in gut wall and activation of efferent vagus bundles are crucial events. Before investigating the effect of high-fat nutrition in clinical setting, suitable markers of inflammation and organ damage need to be selected. In this study, blood will be collected in patients undergoing different types of operations. Consequently several markers for inflammation and organ damage will be determined. Hence, suitable parameters for a future high-fat intervention study will be selected.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 24
- > 18 years
- elective liver / colon / femur surgery
- Acute inflammation
- Chronic Obstructive Respiratory Disease
- Recent history of abdominal pain or diarrhea
- BMI < 18.5
- Alcohol or Drugs abuses
- Recent intake of antibiotics
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description III Blood collection Femur Fracture I Blood collection Liver surgery II Blood collection Colon surgery
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Maastricht University Hospital
🇳🇱Maastricht, Limburg, Netherlands