The Anti-inflammatory Effects of High-fat Nutrition; Towards a Clinical Application

Early Phase 1

Completed

• Conditions: Trauma

• Registration Number: NCT00468507
• Lead Sponsor: Maastricht University Medical Center

Brief Summary

Patients undergoing major surgery, trauma and burns are prone to develop an exacerbated inflammatory response, which is potentially lethal to the individual. Recently our group demonstrated that administration of high fat feeding prior to hemorrhagic shock attenuates severe inflammation, gut barrier loss and hepatic damage. High fat feeding releases cholecystokinin in the gut, which stimulates the autonomous nervous system and subsequently activates the efferent vagus nerve. The activated efferent fibers inhibit tissue macrophages via binding of acetylcholine to the alpha7-nicotinergic receptor.

In this study the cholecystokinin release in healthy volunteers is monitored in response to low fat and high fat food products.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-03
• Study First Submitted: 2007-05-01
• Study First Submitted QC: 2007-05-01
• Study First Posted: 2007-05-02
• Primary Completion: 2010-02
• Status Verified: 2010-03
• Study Completion: 2010-03
• Last Update Submitted: 2010-03-30
• Last Update Posted: 2010-03-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• Healthy males and females
• 45 > age <55

Exclusion Criteria

• Gastrointestinal diseases
• Inflammatory conditions

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
CCK-release	two hours

Trial Locations

Locations (1)

University Maastricht; 🇳🇱 Maastricht, Limburg, Netherlands