Effect of Consuming Oat Bran Mixed in Water Before a Meal on Glycemic Responses in Healthy Humans - a Pilot Study

Not Applicable

Completed

• Conditions: Glucose Intolerance
• Interventions: Other: 0 grams oat bran; Other: 4.5 grams oat bran; Other: 13.6 grams oat bran; Other: 27.3 grams oat bran

• Registration Number: NCT02801916
• Lead Sponsor: Glycemic Index Laboratories, Inc

Brief Summary

Viscous dietary fibers including oat β-glucan are one of the most effective classes of functional food ingredients for reducing postprandial blood glucose. The mechanism of action is thought to be via an increase in viscosity of the stomach contents that delays gastric emptying and reduces mixing of food with digestive enzymes, which, in turn, retards glucose absorption. Previous studies suggest that taking viscous fibers separate from a meal may not be effective in reducing postprandial glycemia. The purpose of this study is to re-assess the effect of consuming a preload of a commercially available oat-bran (4.5, 13.6 or 27.3 g) containing 22% of high molecular weight oat β-glucan (O22) mixed in water before a test-meal of white bread on glycemic responses in 10 healthy humans.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-04
• Primary Completion: 2015-05
• Study Completion: 2015-05
• Status Verified: 2016-06
• Study First Submitted: 2016-06-13
• Study First Submitted QC: 2016-06-15
• Last Update Submitted: 2016-06-15
• Study First Posted: 2016-06-16
• Last Update Posted: 2016-06-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Healthy subjects

Exclusion Criteria

• Pregnancy
• Diabetes
• Recent medical or surgical hospitalization
• Use of drugs influencing glucose metabolism
• Use of drugs influencing gastrointestinal function
• Allergy to oats or wheat

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Study subjects	27.3 grams oat bran	Each healthy subject will receive each of the interventions in randomized order.
Study subjects	4.5 grams oat bran	Each healthy subject will receive each of the interventions in randomized order.
Study subjects	0 grams oat bran	Each healthy subject will receive each of the interventions in randomized order.
Study subjects	13.6 grams oat bran	Each healthy subject will receive each of the interventions in randomized order.

Primary Outcome Measures

Name	Time	Method
Glucose AUC	0 to 2 hours after test meal	Incremental area under the blood glucose response curve from 0 hours (fasting) to 2 hours after eating ignoring area below fasting

Secondary Outcome Measures

Name	Time	Method
Peak rise of blood glucose	0 to 2 hours after test meal	Highest concentration of blood glucose within 2 hours of eating minus the fasting glucose concentration