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临床试验/NCT02801916
NCT02801916已完成不适用

Effect of Consuming Oat Bran Mixed in Water Before a Meal on Glycemic Responses in Healthy Humans - a Pilot Study

Glycemic Index Laboratories, Inc0 个研究点目标入组 10 人开始时间: 2015年4月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
10
主要终点
Glucose AUC

研究概览

简要总结

Viscous dietary fibers including oat β-glucan are one of the most effective classes of functional food ingredients for reducing postprandial blood glucose. The mechanism of action is thought to be via an increase in viscosity of the stomach contents that delays gastric emptying and reduces mixing of food with digestive enzymes, which, in turn, retards glucose absorption. Previous studies suggest that taking viscous fibers separate from a meal may not be effective in reducing postprandial glycemia. The purpose of this study is to re-assess the effect of consuming a preload of a commercially available oat-bran (4.5, 13.6 or 27.3 g) containing 22% of high molecular weight oat β-glucan (O22) mixed in water before a test-meal of white bread on glycemic responses in 10 healthy humans.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Prevention
盲法
None

入排标准

年龄范围
18 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Healthy subjects

排除标准

  • Pregnancy
  • Recent medical or surgical hospitalization
  • Use of drugs influencing glucose metabolism
  • Use of drugs influencing gastrointestinal function
  • Allergy to oats or wheat

结局指标

主要结局

Glucose AUC

时间窗: 0 to 2 hours after test meal

Incremental area under the blood glucose response curve from 0 hours (fasting) to 2 hours after eating ignoring area below fasting

次要结局

  • Peak rise of blood glucose(0 to 2 hours after test meal)

研究者

申办方类型
Industry
责任方
Sponsor

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