Multicountry Studies on the Effect of Positional Distribution of Fatty Acids at Triglyceride Backbone on Serum Lipids, Lipoprotein(a) and LDL-subclasses in Healthy Malaysian Volunteers
- Conditions
- Cardiovascular Risk Factor
- Registration Number
- NCT02802904
- Lead Sponsor
- Malaysia Palm Oil Board
- Brief Summary
Fats and oils are made up of \>90% triacylglycerol fat molecules which consist of a glycerol backbone to which 3 esterified fatty acids are attached. The positions of fatty acid attachment are referred to by stereospecific numbers, sn -1, -2 and -3. There is existing evidence to show that vegetable oils having unsaturated fatty acids in the sn-2 position with predominantly palmitic acid (16:0) or stearic acid (18:0) in the sn-1 and sn-3 positions of fat molecules do not raise serum cholesterol levels. These observations have come to be known as or explained by the "sn-2 hypothesis". New evidence have also emerged to show that saturated fatty acids (16:0, 18:0) in the sn-1 and -3 positions reduces fat deposition in a rat model. In this proposed study, the effects on the outcome measures investigated of three test fats \[namely palm olein IV64 (POP), virgin olive oil (OOO) and cocoa butter (POS)\], with oleic acid primarily at the sn-2 position but differing amounts of palmitic, stearic and oleic acids at the sn-1/sn-3 positions of the triglyceride molecule, are investigated
- Detailed Description
To investigate the effects of different dietary fats with primarily oleic acid in the sn-2 position on the cardiovascular risk profile in healthy Malaysian volunteers
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 42
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Changes of Ratio of total cholesterol to HDL cholesterol (TC:HDL) week 0 (baseline) and week 4 analyzed enzymatically by Siemens Advia 2400 Chemistry Analyzer
- Secondary Outcome Measures
Name Time Method changes of serum Lp(a) week 0 (baseline) and week 4 analyzed enzymatically by Siemens Advia 2400 Chemistry Analyzer
changes of serum HDL cholesterol week 0 (baseline) and week 4 analyzed enzymatically by Siemens Advia 2400 Chemistry Analyzer
changes of Blood pressure week 0 (baseline) and week 4 measured by blood pressure meter
changes of serum non-esterified fatty acids (NEFA) week 0 (baseline) and week 4 analysed by ELISA kits
changes of Waist circumference week 0 (baseline) and week 4 changes of serum LDL cholesterol week 0 (baseline) and week 4 analyzed enzymatically by Siemens Advia 2400 Chemistry Analyzer
changes of serum LDL sub-fractions week 0 (baseline) and week 4 analysed with LIPOPRINT System
Changes of body mass index (BMI) week 0 (baseline) and week 4 measured by Tanita Segmental Body Fat Analysis
changes of serum Triacylglycerol (TAG) week 0 (baseline) and week 4 analyzed enzymatically by Siemens Advia 2400 Chemistry Analyzer