The effects of dietary fatty acids on postprandial markers for inflammation in healthy overweight me

Completed

• Conditions: 10011082; 10000546; 10003216; arteriosclerosis; hardening of the arteries; insulin resistance syndrome; atherosclerosis; metabolic syndrome; syndrome X

• Registration Number: NL-OMON32478
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 15

Inclusion Criteria

men
BMI in the range of 25-30 kg/m2
age between 18 and 70
no treatment with lipid-lowering (Dutch Cholesterol Concensus)

Exclusion Criteria

- Women
- Plasma triacylglycerol >= 1.7 mmol/L (150 mg/dL)
- Smoking
- Lipid-lowering medication/therapy
- Familial hypercholesterolemia
- Use of drugs
- Alcohol consumptions >14/week
- Unstable body weight (weight gain or loss > 3 kg in the past three months)
- Severe medical conditions, which might interfere with the study, such as epilepsy, asthma, COPD,
inflammatory bowel diseases and rheumatoid arthritis.
- Active CVD or recent event in the past 6 months (acute myocardial infarction, stroke)
- Participation in another intervention study within 1 month preceding the screening visit
- Blood donation within 1 month prior to the screening visit or planning to do so during the study
- Impossible or difficult venapunction during screening

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study endpoints are levels of interleukin-6 and levels of other<br /><br>markers of postprandial inflammation, including TNF-alpha, MCP-1, interleukin-1<br /><br>and interleukin-8. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters include markers of insulin resistance, plasma lipids<br /><br>and lipoproteins.</p><br>