Symptom Tracking in Women With a History of Depression Going Through Infertility Treatment.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 49
- 试验地点
- 1
- 主要终点
- Depression relapse
研究概览
简要总结
This study assesses risk factors for depressive relapse in women undergoing fertility treatment with histories of major depressive disorder (MDD) or bipolar disorder. The study is focused on the acute risk factors of depressive relapse.
The investigators hypothesize that risk for depressive relapse will be greater among women who stop antidepressants compared to those who continue treatment with these agents.
详细描述
This study hopes to address the following aims:
Specific Aim #1: To delineate the relative risk of relapse in women undergoing IVF, IUI, or other infertility treatments who discontinue antidepressant therapy for depression, compared to those who maintain treatment with these agents.
Hypothesis: Risk for depressive relapse will be greater among women who stop antidepressants compared to those who continue treatment with these agents.
Specific Aim #2: To identify predictors of depressive relapse among women receiving IVF, IUI, or other infertility treatments
Hypothesis: Relapse rates will be greater among those who have: 1) histories of more recurrent depressive illness, 2) longer duration of attempt to conceive, and 3) a lower degree of perceived support from respective partners.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Have a history of a MDE or bipolar disorder prior to starting fertility treatment.
- •Have received consultation around infertility treatment and plan to start fertility treatment.
排除标准
- •Use of corticosteroids within 1 month of enrollment.
- •Presence of any endocrine or autoimmune disorder, other than hypothyroidism well-treated for at least 6 months.
- •Current episode of depression or mania.
结局指标
主要结局
Depression relapse
时间窗: six months
次要结局
未报告次要终点
研究者
Marlene P. Freeman, MD
Director of Clinical Services at the Center for Women's Mental Health
Massachusetts General Hospital