The Association of Transgelin-2, Metallothionein-2 and Ezrin With Asthma: A Case-control Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Difference in gene expression of transgelin-2, metallothionein-2 and ezrin between controls and asthmatic patients
研究概览
简要总结
Asthma is one of the most common chronic respiratory diseases. Previous study found a series of differentially expressed genes and proteins (transgelin-2, metallothionein-2, ezrin) in asthmatic rat. The aim of the study is to investigate the changes and associations of these gene with asthma in human.
详细描述
This study will investigate the changes and associations in asthma. In this project, the investigators will explore the changes of gene expression of transgelin-2, metallothionein-2 and ezrin in asthma and investigate their correlation with current diagnosis markers of asthma, including pulmonary function, fractional exhaled nitric oxide,eosinophil counts,immunoglobulin E, interleukin-5, etc.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 14 Years 至 75 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Males or females, aged 14-75 years;
- •Patients with a definite diagnosis of bronchial asthma;
- •The diagnosis of asthma according to the Global Initiative for Asthma (GINA), with positive bronchodilator responsiveness (reversibility) test;
- •Healthy volunteers without respiratory symptoms such as cough, wheezing, chest tightness or dyspnea;
- •Agree with all procedures in this trial by signing a written informed consent form.
排除标准
- •Patients with chronic obstructive pulmonary disease or other airway disease;
- •Complicated with other severe primary diseases (including hypertension, cancer, hyperthyroidism, bronchiectasia, cardiac insufficiency) and conditions that would prevent participation in the trial or put the participant at risk;
- •Women who are known to be pregnant or breastfeeding;
- •Not willing to participate;
- •Psychiatric history and neurological disorders can not work normally;
- •Other conditions that the researcher considers inappropriate to participate in this study.
结局指标
主要结局
Difference in gene expression of transgelin-2, metallothionein-2 and ezrin between controls and asthmatic patients
时间窗: Two year
PCR test of gene expression of transgelin-2, metallothionein-2 and ezrin between controls and asthmatic patients
Association of transgelin-2, metallothionein-2 and ezrin with asthma
时间窗: Two year
Correlation analysis between gene expressions of transgelin-2, metallothionein-2, ezrin and current asthmatic tests (pulmonary function, fractional exhaled nitric oxide,immunoglobulin E, serum eosinophil counts, interleukin-5, etc)
次要结局
未报告次要终点