Improving outcomes from exposure therapy for post-traumatic stress disorder (PTSD) with acute exercise: Augmenting Brain Derived Neurotrophic Factor (BDNF) as a mechanism of change?

Not Applicable

Recruiting

• Conditions: Post-traumatic Stress Disorder (PTSD); Depression; Mental Health - Other mental health disorders; Mental Health - Depression

• Registration Number: ACTRN12619001331123
• Lead Sponsor: The University of Melbourne

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-09-30
• Last Update Posted: 1 November 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 112

Inclusion Criteria

(a) aged between 18 and 70 years old
(b) Meeting diagnostic threshold for PTSD on the MINI 7 (PTSD module) after experiencing a traumatic event (at any time-point in their life)
(c) Provision of consent to partake in therapy
(d) English comprehension at a level to make informed consent
(e) If on psychotropic medication, on a stable dose for the last 4 weeks, and not intending to change for the duration of the treatment phase

Exclusion Criteria

(a) Having a medical condition which may put the individual at risk of adverse consequences (e.g., cardiac, respiratory or neuromuscular disorders)
(b) Active mania or psychosis or suicidal ideation or other active risk
(c) Cognitive impairment
(d) Severe alcohol or substance use disorder
(d) Currently receiving psychological treatment (involving exposure therapy or Cognitive Behavioural Therapy for PTSD)
(e) History of moderate to severe traumatic brain injury, neurological disorder or epilepsy
(f) Significant other medical illness
(g) Hormonal or menstrual disorders, pregnancy or breast-feeding
(h) Beta-blocker use
(i) Weighing over 125kg

Study & Design

• Study Type: Interventional
• Study Design: Not specified