The Effect of Using Desensitizers Containing S-PRG In Treatment Of Dentin Hypersensitivity Over 6 Months: A Randomized Clinical Trial

Not Applicable

Not yet recruiting

• Conditions: Dentin Hypersensitivity
• Interventions: Procedure: Tooth varnish (Clinpro white varnish 3M); Procedure: Tooth varnish (PRG Barrier Coat from Shofu)

• Registration Number: NCT06276777
• Lead Sponsor: Eman Omar Elfarouk

Brief Summary

The goal of this clinical trial is to compare the effect of desensitizer containing S-PRG have similar effect as sodium fluoride with functionalized tri-calcium phosphate containing desensitizer in relieving dentinal hypersensitivity in adult patients for six months follow-up. patients will be asked to report pain degree on the visual analogue scale (VAS) along the follow up periods on both groups.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-02
• Study First Submitted: 2024-02-01
• Study First Submitted QC: 2024-02-23
• Last Update Submitted: 2024-02-23
• Study First Posted: 2024-02-26
• Last Update Posted: 2024-02-26
• Study Start: 2024-05-01
• Primary Completion: 2024-11-01
• Study Completion: 2024-12-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Good oral hygiene.
• Cooperative patients who show interest to participate in the study and welling to sign the informed consent.
• Healthy patients with no history of previous systematic diseases that can affect their oral health.
• Normal and healthy gingival tissue.
• Teeth that have no cavitation or restorations.
• Patients with at least 20 natural permanent teeth and at least two teeth with a VAS score from 4 to 10.
• Anterior teeth.

Exclusion Criteria

• Allergic to the ingredients used in the study.
• Gastrointestinal disorders (They have repeated vomiting attacks).
• Medically compromised (They cannot tolerate the procedures).
• Taking desensitizing treatment in the last 6 months (It affects the outcome).
• Taking anti-inflammatory drugs (It affects the hypersensitivity perception).
• Pregnant females (They complain from nausea and repeated vomiting attacks)
• Smokers (Smoking will affect the oral hygiene and periodontal health).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Varnish contains sodium fluoride and functionalized tri-calcium phosphate(Clinpro white varnish 3M)	Tooth varnish (Clinpro white varnish 3M)	Treatment of dentin hypersensitivity by application of tooth varnish containing sodium fluoride with functionalized tri-calcium phosphate.
Varnish contains S-PRG (PRG Barrier Coat from Shofu)	Tooth varnish (PRG Barrier Coat from Shofu)	Treatment of dentin hypersensitivity by application of tooth varnish containing S-PRG.

Primary Outcome Measures

Name	Time	Method
Dentin hypersensitivity reduction	assessment will be done immediately after the treatment then after 1 week, 4 weeks, 3 months and 6 months.	The participants will point out the degree of sensitivity on the VAS scale (0-10) chart.

Trial Locations

Locations (1)

Faculty of Dentistry Cairo University; 🇪🇬 Cairo, Egypt