Analysis of the Influence of Desensitizing Treatments on the Pulp Inflammatory Response in Bleached Teeth

Not Applicable

Completed

• Conditions: Pulp Inflammation
• Interventions: Other: Whiteness HP 35%; Other: Whiteness HP 35% + CPP; Device: Whiteness HP 35% + LASER; Other: Whiteness HP 35% + NANO

• Registration Number: NCT04548674
• Lead Sponsor: Universidade Federal do Para

Brief Summary

This randomized, controlled, blinded clinical trial evaluated the effectiveness of different desensitizing protocols in preventing pulp inflammation after bleaching treatment with 35% hydrogen peroxide (PH) (Whiteness PH 35%).

Detailed Description

Thirty healthy third human molars extracted by orthodontic indication were randomized and allocated into five groups (n = 6): CN (negative control): without intervention; CP (Positive control): PH; PMB: PH + photobiomodulation with low power laser; CPP: PH + casein phosphopeptide phosphopeptide amorphous calcium phosphate (CPP-ACPF); NANO: PH + nanohydroxyapatite. The office whitening was performed in two sessions with a single application of 45 min and an interval of 48 hours between them. Pulp tissues were removed for immunohistochemical analysis. Immunostaining was performed for Caspase 3 using an Axio Scope.A1 microscope.

Study Timeline

• Study Start: 2018-08-20
• Primary Completion: 2019-03-15
• Study Completion: 2019-06-30
• Status Verified: 2020-09
• Study First Submitted: 2020-09-01
• Study First Submitted QC: 2020-09-08
• Last Update Submitted: 2020-09-08
• Study First Posted: 2020-09-14
• Last Update Posted: 2020-09-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
CPP Group	Whiteness HP 35% + CPP	Whiteness HP 35% + CPP
Laser Group	Whiteness HP 35%	Whiteness HP 35% + Laser
Laser Group	Whiteness HP 35% + LASER	Whiteness HP 35% + Laser
Nano Group	Whiteness HP 35%	Whiteness HP 35% + NANO
CPP Group	Whiteness HP 35%	Whiteness HP 35% + CPP
Positive Control Group	Whiteness HP 35%	Whiteness HP 35%
Nano Group	Whiteness HP 35% + NANO	Whiteness HP 35% + NANO

Primary Outcome Measures

Name	Time	Method
Pulp inflammation	3 days After extraction of third molars	Evaluation of pulp inflammation through immunohistochemistry of the third molar whitening or not

Trial Locations

Locations (1)

Universidade Federal do Pará; 🇧🇷 Belém, Pará, Brazil