Effects of Corticotropin Releasing Hormone (CRH) on the Sleep in Patients With Hypopituitarism
- Conditions
- Hypopituitarism
- Registration Number
- NCT00666068
- Lead Sponsor
- Max-Planck-Institute of Psychiatry
- Brief Summary
In contrast to healthy subjects, patients with hypopituitarism do not exhibit endocrine responses when hormones are injected. This is at least true for those with a complete insufficiency of the anterior pituitary. For example, administration of corticotropin releasing hormone (CRH) is not followed by an increase of ACTH and cortisol. Therefore, "pure" hormone effects can be investigated.
It is well established that hormones of the hypothalamic-pituitary-adrenal axis are involved in sleep regulation. In rodents, CRH decreased slow wave sleep (SWS). In humans, CRH was reported to increase wakefulness and to decrease SWS and REM sleep. Primary objective was therefore to study the effect of CRH on patients with hypopituitarism.
To date, there is no information on sleep of patients with hypopituitarism. Secondary objective is therefore to compare sleep of patients with hypopituitarism with sleep of age-matched healthy controls.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
- Age 18-75 years
- Complete insufficiency of the anterior pituitary
- Stable hormone substitution for at least 3 months
- Hormone excess in the past
- Sleep disorder, e.g. sleep apnea syndrome
Healthy controls
Inclusion Criteria:
- Age 18-75 years
Exclusion Criteria:
- Any medication during 6 week prior to study entry
- Shift work
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Sleep-EEG variables, conventionally and quantitatively analyzed within the first month
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Max Planck Institute of Psychiatry
🇩🇪Munich, Germany
Max Planck Institute of Psychiatry🇩🇪Munich, Germany