Impairment of Central Coherence in Restrictive Anorexia Nervosa (CoCA)
- Conditions
- Anorexia Nervosa
- Interventions
- Behavioral: One interview of 90 minutes with a part of cognitive assessment and a part of self-assessment
- Registration Number
- NCT02381639
- Lead Sponsor
- Nantes University Hospital
- Brief Summary
The current etiological pathological model of anorexia nervosa is poly-factorial involving individual genetic and psychological factors, in close interaction with environmental, family and socio-cultural factors.
Among these factors, this study focuses on the central coherence process (cognitive ability to integrate complex information into a comprehensive meaning), in the active phase of the disease. Therefore, patients followed in the addiction service of the Nantes University Hospital will perform neuropsychological tests assessing executive functions involved in the process of central coherence.
Impairment of central coherence process could act as a maintenance factor of the disease, particularly in connection with body dysmorphic disorder. The therapeutic perspectives acting on the central coherence process like cognitive remediation deserve to deepen knowledge on the cognitive profile of patients with anorexia nervosa.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 122
-
For the patients :
- Woman.
- Aged of more than 15 years and 3 months.
- Followed in the addiction service of the University Hospital of Nantes (consultations and / or hospitalizations) for Restrictive Anorexia Nervosa (according to the diagnostic criteria of DSM-IV-TR).
- French language mastered.
- Having signed the consent if major and if not the legal representatives have signed the consent (for minors).
-
For the volunteers :
- Women.
- Aged of more than 15 years and 3 months.
- French language mastered.
- Having signed the consent if major and if not the legal representatives have signed the consent (for minors).
-
For the patients :
-
Man
-
Age under 15 years and 3 months old
-
Current Renutrition by nasogastric tube
-
Personal history of:
- Head injury, neurodegenerative diseases, epilepsy unbalanced, unbalanced endocrine disorder, mental retardation
- Support for current or past cognitive remediation
-
Opposition of the patient and / or his legal representatives if minor
-
Subject under legal guardianship
-
Current participation or in the past to pharmacological research protocol (time since the end of their participation in the protocol less than one year)
-
French language not mastered
-
-
For the volunteers :
-
Man
-
Age under 15 years and 3 months old
-
Current Renutrition by nasogastric tube
-
Personal history of:
- Eating disorders
- Head injury, neurodegenerative diseases, epilepsy unbalanced, unbalanced endocrine disorder, mental retardation
- Support for current or past cognitive remediation
-
Opposition of the volunteer and / or his legal representatives if minor
-
Subject under legal guardianship
-
Current participation or in the past to pharmacological research protocol (time since the end of their participation in the protocol less than one year)
-
French language not mastered
-
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Healthy volunteers One interview of 90 minutes with a part of cognitive assessment and a part of self-assessment control subjects matched for age and sex with the patients Patients One interview of 90 minutes with a part of cognitive assessment and a part of self-assessment patients followed in the addiction service of the University Hospital of Nantes (consultations and / or hospitalizations) for restrictive anorexia nervosa
- Primary Outcome Measures
Name Time Method Percentages for types I and III of the copy of the figure of Rey 90 minutes
- Secondary Outcome Measures
Name Time Method Average scores for all cognitive and psychiatric tests 90 minutes Measure of relationships between average scores for all cognitive and psychiatric tests and socio-demographic and clinical data 90 minutes
Trial Locations
- Locations (1)
CHU de Nantes, Service d'Addictologie
🇫🇷Nantes, France