Erythrocyte Glutamine Level Relation to Pulmonary Hypertension Risk in Beta Thalassemia Major Children in Assiut University Children Hospital

Assiut University1 site in 1 country80 target enrollmentJune 1, 2017

ConditionsThalassemia in Children Pulmonary Hypertension Hemolysis

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Thalassemia in Children
Sponsor: Assiut University
Enrollment: 80
Locations: 1
Primary Endpoint: Erythrocyte glutamine level
Status: Completed
Last Updated: 6 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The study will investigate the relation between erythrocyte glutamine/glutamate ratio and pulmonary hypertension risk in Egyptian thalassemic children in Assiut University Children Hospital

Registry

clinicaltrials.gov

Start Date

June 1, 2017

End Date

August 26, 2019

Last Updated

6 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Assiut University

Responsible Party

Principal Investigator

Fatma Sami

Pediatric Resident

Assiut University

Eligibility Criteria

Inclusion Criteria

•Established diagnosis of Thalassemia.
•PH risk documented by doppler echocardiography, defined as tricuspid regurge velocity (TRV) equal to or greater than 2.5 m/s

Exclusion Criteria

•Acute crisis or hospitalization within 1 month of enrollment
•Hepatic dysfunction (SGPT greater than 3X normal)
•Renal dysfunction (Creatinine greater than 2X normal)
•Patients on sildenafil (Viagra), calcium channel blockers or other drugs for the control of PH.