NCT05623033招募中不适用
The Predictive Value of Dynamic Changes of CD4+T Lymphocytes in Primary Nephrotic Syndrome With Infection
Fifth Affiliated Hospital, Sun Yat-Sen University1 个研究点 分布在 1 个国家目标入组 156 人开始时间: 2022年11月16日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 156
- 试验地点
- 1
- 主要终点
- Dynamic changes of CD4+T cells
研究概览
简要总结
The goal of this observational study is to test whether the dynamic changes of CD4+T lymphocytes can predict infections in patients with primary nephrotic syndrome . The main questions it aims to answer are:
- whether the dynamic changes of CD4+T lymphocytes can predict infections in patients with primary nephrotic syndrome
- effect of different immunosuppressive therapy on the number and function of T lymphocyte subsets in patients with primary nephrotic syndrome
Participants will be divided into infection group and non-infection group according to whether they are infected
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 14 Years 至 75 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥ 14 years and<75 years.
- •It meets the diagnostic criteria of primary nephrotic syndrome, i.e. a. A large amount of proteinuria (24h urine protein quantity > 3.5g/d); b. Hypoalbuminemia (liver function: albumin<30g/L); c. Edema; d. The blood lipid is elevated. Among them, item a and b are necessary conditions for diagnosis.
- •Nephrocentesis pathology indicates the pathological type of nephrotic syndrome (minimal change glomerulonephritis, membranous nephropathy, focal segmental glomerulonephritis, membranous proliferative glomerulonephritis, mesangial proliferative glomerulonephritis).
- •Glucocorticoids or corticosteroids combined with immunosuppressants should be used clinically.
排除标准
- •Secondary nephrotic syndrome, such as secondary to systemic lupus erythematosus, hepatitis B, hepatitis C, tumor, organic solvent , heavy metal poisoning, etc.
- •Patients with tumor and chronic infectious diseases, such as HIV infection, cardiac insufficiency, acute hepatitis, transaminase increase more than twice the normal value, deep vein thrombosis.
- •The subjects were pregnant and lactating women.
- •Patients with serious primary diseases such as heart, brain, liver and hematopoietic system.
- •Those who can not cooperate, such as the mentally ill.
- •It is known that it is allergic to or has contraindications to any component in glucocorticoid, FK506, MMF and CTX.
- •Serum creatinine (SCR) > 265.2 μ mol/L（3mg/dl）。
结局指标
主要结局
Dynamic changes of CD4+T cells
时间窗: 3 years after the project starts
Whether the change of CD4+T lymphocytes count can predict infections in patients with primary nephrotic syndrome
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
尚未招募
不适用
DNA Methylation Trajectories in AgingAgingHeart FailureNCT06582992University of Campania "Luigi Vanvitelli"150
Unknown
不适用
A Prospective Study of Monitoring Immune Response in Locally Advanced Cervix CancerCervical CancerNCT03559803Sichuan University58
终止
4 期
Adaptive Immune Responses and Repertoire in Influenza Vaccination and Infection (SLVP031)InfluenzaNCT03028987Stanford University10
进行中（未招募）
不适用
Bioclinical Evaluation of 2 Biomarkers of Aviremic HIV-1 in CD4+ T Cells of Adults Undergoing TreatmentHIV-1-infectionNCT03940521Centre Hospitalier Universitaire de Nīmes48
尚未招募
Unknown
Evaluation of CD4 T cell count and its subsets in patients with major depressive disorderCTRI/2024/07/071516Maulana Azad Medical College