EPIGENETIC-SENSITIVE BIOMARKERS OF INFLAMMAGING FROM HEALTHY TO HEART FAILURE DISEASE
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Number of differentially methylated positions and regions as assessed by RRBS
研究概览
简要总结
The goal of this observational study is to profile changes in DNA methylation of circulating CD4+ T and CD8+ T cells from healthy young to aged with diagnosis of HFpEF, a particular phenotype of HF which is highly prevalent in aging.
The main question it aims to answer is:
-Do DNA methylation biomarkers help us to understand the role of inflammation in HFpEF during aging?
Our goal is to provide a simple large-scale panel of epigenetic-sensitive biomarkers useful in aged patients with HF in the early natural history of the disease (HFpEF).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Healthy subjects aged between 18 and 40 years
- •Aged subjects (≥65) without signs and symptoms of heart failure
- •Aged subjects (≥65) with diagnosis of heart failure with preserved ejection fraction (EF major than 50%)
排除标准
- •Heart failure with reduced ejection fraction (EF minor than 40%)
- •Heart failure with mildly reduced EF (HFmrEF) (EF 41-49%)
- •History or diagnosis of cancer and inflammatory diseases
结局指标
主要结局
Number of differentially methylated positions and regions as assessed by RRBS
时间窗: 6 months
We will identify a panel of positions and regions of the genome which are differentially methylated using as measure diff.meth more than or minor than 2 and p minor than 0.05
次要结局
未报告次要终点
研究者
Giuditta Benincasa
Principal Investigator
University of Campania "Luigi Vanvitelli"