PET/MRI/EEG Imaging Study in Epilepsy
- Conditions
- Epilepsy
- Registration Number
- NCT06974305
- Lead Sponsor
- Massachusetts General Hospital
- Brief Summary
This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography \[FDG-PET\], and blood flow, measured by functional magnetic resonance imaging \[fMRI\]) relate to abnormal interictal electrical activity associated with epilepsy (measured by electroencephalography \[EEG\]). The study will also compare how the three imaging modalities localize regions of abnormal function in the brain.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 30
- Age 18 or older
Additional Inclusion Criteria for Subjects with Epilepsy:
- Diagnosed with epilepsy with abnormal interictal EEG
- Contraindications to PET, MRI, or EEG imaging
- History of severe brain disease such as stroke and head trauma
- History of brain surgery
- History of type I or II diabetes mellitus
- Fasting plasma glucose level >200 mg/dL
- Employed under direct supervision of the PI conducting the research
Additional Exclusion Criteria for Healthy Subjects:
- Current use of drugs that modulate brain function
- Current or past history of major medical, neurological, or psychiatric conditions
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Image analysis Image analysis to be performed after imaging sessions are complete. There are no interventions in this study and thus no outcome measures. Primary goal of the study will be achieved with image analysis on the PET/MRI/EEG data.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Athinoula A. Martinos Center
🇺🇸Charlestown, Massachusetts, United States