Beverage Hydration Index: Assessment of Four Rehydration Solutions
- Conditions
- Hydration
- Registration Number
- NCT06272435
- Lead Sponsor
- University of Memphis
- Brief Summary
No studies to date to evaluate the effects of the three different liquid IV electrolyte products on the beverage hydration index (BHI). Therefore, the purpose of this study is to determine the impact of three different LIV products (Hydration multiplier, Sugar Free formulation with Amino Acids, and Sugar Free with allulose) on hydration status in young and active men and women compared to a control (water). The study will follow the same approach as used by Maughan and colleagues (2016) to measure the fluid balance (the difference between the amount of water consumed and passed as urine) and BHI (the relative amount of urine passed after consumption of a drink compared to water) including time in positive fluid balance, as well as determining electrolyte concentrations, osmolality, specific gravity, and sodium and potassium in urine.
- Detailed Description
Many attempts have been made to improve and measure the hydration status of active individuals. This typically involves the ingestion of fluids leading up to activity (typically plain water), as well as the ingestion of fluids during the activity itself (water, along with a diluted carbohydrate/electrolyte beverage). This approach seems to work well; however, some debate remains over what the best fluid is to consume, in particular related to the macronutrient type and the specific electrolyte mix.
No studies to date to evaluate the effects of the three different liquid IV electrolyte products on the beverage hydration index (BHI). Therefore, the purpose of this study is to determine the impact of three different LIV products (Hydration multiplier, Sugar Free formulation with Amino Acids, and Sugar Free with allulose) on hydration status in young and active men and women compared to a control (water). The study will follow the same approach as used by Maughan and colleagues (2016) to measure the fluid balance (the difference between the amount of water consumed and passed as urine) and BHI (the relative amount of urine passed after consumption of a drink compared to water) including time in positive fluid balance, as well as determining electrolyte concentrations, osmolality, specific gravity, and sodium and potassium in urine.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 28
- body mass index (BMI) <35 kilgrams per square meter
- consistent dietary intake and exercise throughout study period
- consumes 2 liters (women) or 2.5 liters (men) of water per day prior to study visits
- able to fast for 15 hours
- sensitivity or be allergic to any components of the study product they will be excluded.
- tobacco user
- specialized diet (low carbohydrate/ketogenic diet, carnivore diet, intermittent fasting, etc.)
- caffeine consumption within 12 hours of study visit
- strenuous activity within 24 hours of study visit
- history or presence of a clinically relevant (that required or requires treatment) cardiac, renal, hepatic, endocrine (including diabetes mellitus), pulmonary, biliary, gastrointestinal, pancreatic, or neurologic disorder
- conditions that alter fluid balance or electrolytes/hydration status
- consuming any medication which may alter fluid retention/electrolyte levels such as sodium-glucose co-transporter 2 (SGLT2) inhibitor (for type 2 diabetes), laxatives, diuretics, Apremilast, chemotherapy, or lithium.
- consuming nutritional supplements, performance enhancing drugs, and/or non-steroidal anti-inflammatory drugs within 7 days of study visits excluding screening).
- employee of Liquid IV
- be enrolled in another clinical study within 30 days of the first study visit
- active infection or illness of any kind
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Beverage Hydration Index 240 minutes after beverage consumption Beverage Hydration index calculated as mass of urine collected following control (water) consumption divided by the mass of urine collected following treatment.
- Secondary Outcome Measures
Name Time Method Urine Specific Gravity 240 minutes after beverage consumption urine Urine Specific Gravity will be measured via refractometry.
Sodium balance 240 minutes after beverage consumption Sodium Balance will be calculated subtracting total sodium in urine from total sodium consumed in beverage.
Body Mass 240 minutes after beverage consumption Body Mass in kilograms will be measured using a digital scale
Net Fluid Balance 240 minutes after beverage consumption Net Fluid balance will be calculated subtracting total urine collected from total liquid consumed
Mood and Digestive Questionnaire 240 minutes after beverage consumption Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme)
Urine Potassium 240 minutes after beverage consumption Urine Potassium will be measured in millimoles per liter.
Urine Sodium 240 minutes after beverage consumption Urine Sodium will be measured in millimoles per liter.
Potassium balance 240 minutes after beverage consumption Potassium Balance will be calculated subtracting total potassium in urine from total potassium consumed in beverage.
Urine Osmolality 240 minutes after beverage consumption Urine Osmolality will be measured in milliosmoles per kilogram of water.
Trial Locations
- Locations (1)
Center for Nutraceutical and Dietary Supplement Research
🇺🇸Memphis, Tennessee, United States
Center for Nutraceutical and Dietary Supplement Research🇺🇸Memphis, Tennessee, United States