Effect of Lower Body Negative Pressure and Angiotensin II Receptor Blockade on Renal Hemodynamic, Neuro-hormonal and Tubular Response in Pre-hypertensive States: a Randomized Controlled Trial.
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 78
- 试验地点
- 1
- 主要终点
- sodium excretion
研究概览
简要总结
The purpose of this study is to determine whether in pre-hypertensive and hypertensive states such as white coat hypertension, obesity related hypertension or resistant hypertension, renal function is more sensitive to orthostatic stress.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI > 30 Kg/m2 (obesity group)
- •office BP >140/90 and daytime ambulatory blood pressure <135/85 (white coat hypertension group) _daytime abpm >135/85 mm Hg or nighttime abpm 120/70
排除标准
- •History of allergic reaction
- •Diabetes type 1 or type 2
- •History of renal artery stenosis
- •Acute illness
研究组 & 干预措施
control group
healthy volunteer
干预措施: Lower body negative pressure (LBNP) (Other)
control group
healthy volunteer
干预措施: Candesartan cilexetil (Drug)
obesity group
Patients with BMI >30 Kg/m2
干预措施: Lower body negative pressure (LBNP) (Other)
obesity group
Patients with BMI >30 Kg/m2
干预措施: Candesartan cilexetil (Drug)
white coat hypertension group
Patients with office blood pressure >140/90 mmHg and ambulatory daytime blood pressure <135/85 mmHg
干预措施: Lower body negative pressure (LBNP) (Other)
white coat hypertension group
Patients with office blood pressure >140/90 mmHg and ambulatory daytime blood pressure <135/85 mmHg
干预措施: Candesartan cilexetil (Drug)
Resistant hypertension
Patients with ambulatory blood pressure > 135/85 mm Hg (day) or >120/70 mm Hg (night) with 3 antihypertensive drugs with direct observance of drug taking.
干预措施: Lower body negative pressure (LBNP) (Other)
结局指标
主要结局
sodium excretion
时间窗: after one hour of lower body negative pressure
sodium excretion will be compared to control group (healthy volunteers) after one hour of lower negative pressure. The protocol includes 2 hours of baseline measure, one hour of lower negative pressure and 2 hours of recovery
次要结局
- glomerular filtration rate(after one hour of lower body negative pressure)
研究者
PD Dr. Grégoire Wuerzner
Doctord, MD, privat docent
Centre Hospitalier Universitaire Vaudois