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临床试验/NCT07200063
NCT07200063尚未招募不适用

Comparative Assessment of Children's Acceptance and Compliance of Mouthwash Containing Silver Nanoparticles Compared to Chlorhexidine Mouthwash: A Randomized Clinical Trial.

Cairo University0 个研究点目标入组 60 人开始时间: 2026年1月1日最近更新:

试验速览

阶段
不适用
状态
尚未招募
入组人数
60
主要终点
children acceptance and compliance

研究概览

简要总结

This study aims to evaluate and compare the children's acceptance of mouthwash containing silver nanoparticles versus Chlorhexidine.

详细描述

Effective management of dental plaque is crucial for preventing periodontal diseases, dental caries, and other oral health complications. Oral hygiene can be maintained through both chemical and mechanical methods. Chemical methods are particularly beneficial in situations where mechanical cleaning proves challenging. Mouthwashes represent a significant chemical strategy for controlling plaque. Among different types of mouthwashes, chlorhexidine is considered the gold standard due to its high efficacy against a broad spectrum of bacteria and its role in plaque management, which helps prevent periodontal diseases. However, it is important to note that chlorhexidine has several side effects, such as numbness, changes in taste perception, dental staining, and an unpleasant bitter taste.

In modern applications, nanotechnology is being utilized more frequently, especially with the integration of nanoparticle materials. Silver nanoparticles, in particular, are widely used in the medical field because of their remarkable antibacterial effects on oral biofilms associated with periodontal disease.

Therefore, this research aims to evaluate the children's acceptance of chlorhexidine mouthwash in children compared to a mouthwash containing silver nanoparticles, as well as to assess their respective impacts on gingivitis.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Supportive Care
盲法
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围
6 Years 至 12 Years(Child)
性别
All
接受健康志愿者

入选标准

  • Children aged from 6 to 12 in good general health and medically free
  • Cooperative patient who will care about attending the follow-up visit
  • Acceptance of the parents to sign the informed consent
  • Composite restoration on anterior teeth

排除标准

  • Children who are unable to attend the follow-up visit
  • Medically compromised patient
  • Handi-capped patient
  • Parents refuse to sign informed consent

结局指标

主要结局

children acceptance and compliance

时间窗: 15 days

it will be measured by likert scale (1-5) 1 (strongly disagree) 5 (strongly agree)

次要结局

  • Gingival health(15 days)
  • plaque thickness at gingival margin(15 days)
  • color stability of composite restoration of anterior teeth(15 days)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ibrahem Mohamed Ibrahem Arafat

Master's student (Dentist)

Cairo University

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