Children Acceptance of AgNP Mouthwash Against Chlorhexidine Mouthwash

Not Applicable

Not yet recruiting

• Conditions: Teeth Staining; Numbness of the Tongue and Soft Tissue; Bitter Taste

• Registration Number: NCT07200063
• Lead Sponsor: Cairo University

Brief Summary

This study aims to evaluate and compare the children's acceptance of mouthwash containing silver nanoparticles versus Chlorhexidine.

Detailed Description

Effective management of dental plaque is crucial for preventing periodontal diseases, dental caries, and other oral health complications. Oral hygiene can be maintained through both chemical and mechanical methods. Chemical methods are particularly beneficial in situations where mechanical cleaning proves challenging. Mouthwashes represent a significant chemical strategy for controlling plaque. Among different types of mouthwashes, chlorhexidine is considered the gold standard due to its high efficacy against a broad spectrum of bacteria and its role in plaque management, which helps prevent periodontal diseases. However, it is important to note that chlorhexidine has several side effects, such as numbness, changes in taste perception, dental staining, and an unpleasant bitter taste.

In modern applications, nanotechnology is being utilized more frequently, especially with the integration of nanoparticle materials. Silver nanoparticles, in particular, are widely used in the medical field because of their remarkable antibacterial effects on oral biofilms associated with periodontal disease.

Therefore, this research aims to evaluate the children's acceptance of chlorhexidine mouthwash in children compared to a mouthwash containing silver nanoparticles, as well as to assess their respective impacts on gingivitis.

Study Timeline

• Status Verified: 2025-06
• Study First Submitted: 2025-09-09
• Study First Submitted QC: 2025-09-28
• Last Update Submitted: 2025-09-28
• Study First Posted: 2025-09-30
• Last Update Posted: 2025-09-30
• Study Start: 2026-01-01
• Primary Completion: 2026-03
• Study Completion: 2026-06-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
children acceptance and compliance	15 days	it will be measured by likert scale (1-5); 1 (strongly disagree) 5 (strongly agree)

Secondary Outcome Measures

Name	Time	Method
Gingival health	15 days	\* gingival inflammation measured by modified gingival index scoring criteria (0-4) 0 (Normal gingiva ) 4 (sever inflammation of gingiva)
plaque thickness at gingival margin	15 days	\* measure plaque thickness at gingival margin by plaque index by loe and silness scoring criteria (0-3) 0 (no plaque) 3 (thick plaque)
color stability of composite restoration of anterior teeth	15 days	measure color stability of composite restoration of anterior teeth ΔE\* = √((L₂ - L₁)² + (a₂ - a₁)² + (b₂ - b₁)²; Where: L\* = Lightness (0 = black, 100 = white); 1. = Red-Green axis (positive = red, negative = green); 2. = Yellow-Blue axis (positive = yellow, negative = blue; * L1, a1, b1 = before exposure; * L2, a2, b2 = after exposure A higher ∆E means more discoloration.