跳至主要内容
临床试验/CTRI/2017/12/010895
CTRI/2017/12/010895已完成不适用

To compare the effectiveness of different mouthrinses on Streptococcus mutans count in caries active children

Institute of Dental Studies and Technologies1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2016年11月2日最近更新:

试验速览

阶段
不适用
状态
已完成
入组人数
60
试验地点
1
主要终点
Reduction in streptococcus mutans level

研究概览

简要总结

The study was conducted in Institute of Dental studies and Technologies in department of Pedodontics and Preventive dentistry. The antimicrobial activity. of Chlorhexidine, Sodium fluoride and Herbal mouth rinse were evaluated for their efficacy against S. mutans in 60 children aged 6-12 years old. Plain water acted as the control group. Aakansha Sharma acted as the primary investigator and Dr. Nidhi Agarwal, Dr. Zohra Jabin, Dr. Ashish Anand were the other co investigators of the study.The values obtained were subjected to statistical analysis. ANOVA test, student-t test and paired t-test were used for evaluation. The ean DMFT/deft of the caries active children was 5.93. There was a statistically significant reduction of S. mutans seen in chlorhexidine and Fluoride mouthrinse group in the pre and post rinse values with a p value of 0.003 and0.028 respectively. Themean Streptococcus mutans count in pre- rinse groups were as follows: In groupI the mean S. mutans count was 1.259 * 105+ 1.174, in GroupII was 0.649* 105 + 0.987, in Group III was 1.624* 105 +2.276 while in Group IV it was 0.795* 105 + 1.427. The mean Streptococcus mutans count in post- rinse groupswere as follows:

In group I the mean S. mutans count was 0.214* 105+0.130,in Group II was 0.297* 105 + 0.446, in Group III was 0.238*105+ 0.217 while in Group IV it was 0.786* 105+1.405. There was a reduction in S. mutans  seen in hiora mouthrinse group however it was not statistically significant with a p- value of 0.057 . Water showed no reduction and a p- value of 0.184 was obtained for it when the pre and post rinse counts were compared. All the mouthrinses used in the present study have shown a definite decline in S. mutans count.

研究设计

研究类型
Interventional
分配方式
Coin toss, Lottery, toss of dice, shuffling cards etc
盲法
Participant, Investigator and Outcome Assessor Blinded

入排标准

年龄范围
6.00 Year(s) 至 12.00 Year(s)(—)
性别
All

入选标准

  • 1.Healthy children between ages of 6-12 years.
  • 2.Patient having one or more than one interproximal carious lesions, well into the dentin, visualized radiographically.
  • 3.All teeth and surrounding tissues were clinically and radiographically free of any other pathologic condition.

排除标准

  • 1.Physical limitations, which might preclude the normal tooth brushing and mouth rinsing.
  • 2.Presence of any intraoral infections.
  • 3.Medically compromised patients or those who were on any long term medication.
  • 4.Subjects with history of taking antibiotics 1 month prior to or during the course of study.

结局指标

主要结局

Reduction in streptococcus mutans level

时间窗: Baseline and 15 days

次要结局

  • Not applicable(Not applicable)

研究者

申办方类型
Research institution and hospital

研究点 (1)

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