In vivo identification of peripheral nerve bundles during surgery using optical spectroscopy techniques: a pilot study

Recruiting

Conditions: haed and neck malignancies
10040900
melanoma
soft tissue tumours
rectal cancer
10040795

Registration Number: NL-OMON37194

Lead Sponsor: Philips

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 22

Inclusion Criteria

•Patients planned for elective inguinal or cervical lymph node dissection, parotidectomy, rectal resection or resection of soft tissue tumour.
•Written informed consent
•Patients >= 18 years old

Exclusion Criteria

•Patients with suspected sensitivity to light; e.g. patients who have had photodynamic therapy

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Several optical spectroscopy parameters of the targeted tissue will be analysed<br /><br>and specified.<br /><br><br /><br>Diffuse reflectance parameters: Oxyhaemoglobin saturation, total haemoglobin<br /><br>content, water and fat content within the tissue as well as 2 scatter<br /><br>coefficients of the tissue.<br /><br><br /><br>Fluorescence parameters: Collagen, elastin, NADH content within the tissue.<br /><br><br /><br>The analysis of the different reflectance and fluorescence parameters will<br /><br>result in a specific tissue fingerprint allowing optical tissue specific<br /><br>characterization of nerve tissue of the hypogastric plexus.<br /><br><br /><br>Primary Objective:<br /><br>In this pilot study we aim to evaluate whether optical spectroscopy is able to<br /><br>differentiate between nerve tissue and surrounding tissue.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary Objective:<br /><br>During the measurement procedure, possible improvements of the measurement<br /><br>hardware will be recorded and the handling during surgery will be evaluated.</p><br>