Perioperative Changes in Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score and Postoperative Outcomes After Esophagectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 131
- 试验地点
- 1
- 主要终点
- Incidence of postoperative complications
研究概览
简要总结
Esophagectomy is associated with substantial postoperative morbidity despite advances in perioperative care. The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score has been proposed as a composite biomarker reflecting nutritional, inflammatory, and immune status; however, its perioperative behavior and clinical significance after esophagectomy remain unclear. This retrospective cohort study evaluates perioperative changes in HALP and examines the associations of preoperative, postoperative day 1, and postoperative day 7 HALP measurements with postoperative complications, including overall and major complications, anastomotic leakage, ICU readmission, and length of hospital stay. The study aims to clarify the potential role of perioperative HALP as a marker of postoperative recovery and adverse clinical outcomes following esophagectomy.
详细描述
Esophagectomy remains the cornerstone of curative treatment for localized esophageal cancer but is associated with a high incidence of postoperative morbidity despite advances in surgical techniques and perioperative care. Early identification of patients at increased risk of postoperative complications remains an important objective in perioperative medicine, as timely recognition of physiological deterioration may facilitate closer monitoring and individualized postoperative management.
The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score is a composite biomarker derived from routinely available laboratory parameters that integrates nutritional, inflammatory, hematologic, and immune status. Previous studies have primarily evaluated preoperative HALP as a prognostic indicator for long-term oncological outcomes in various malignancies. However, limited evidence is available regarding perioperative changes in HALP and whether postoperative HALP measurements provide clinically relevant information following major upper gastrointestinal surgery.
This retrospective cohort study evaluates perioperative HALP measurements obtained before surgery, on postoperative day 1, and on postoperative day 7 in patients undergoing esophagectomy. The study investigates perioperative HALP dynamics and examines the associations between HALP measurements at different time points and clinically relevant postoperative outcomes, including overall complications, major complications, anastomotic leakage, ICU readmission, and length of hospital stay.
The objective of this study is to characterize perioperative changes in HALP and to explore its potential role as a perioperative biomarker associated with postoperative recovery and adverse clinical outcomes after esophagectomy. Findings from this study may contribute to a better understanding of the temporal behavior of HALP following major surgery and inform future prospective studies evaluating its clinical utility in perioperative risk assessment and postoperative monitoring.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18 years or older.
- •Histologically confirmed esophageal cancer.
- •Underwent elective esophagectomy with curative intent between June 2020 and March
- •Available laboratory data for calculation of the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score preoperatively and on postoperative days 1 and
- •Complete clinical data regarding postoperative outcomes
排除标准
- •Age younger than 18 years.
- •Benign esophageal disease or surgery performed for indications other than esophageal cancer.
- •Emergency esophagectomy.
- •Missing laboratory data required for calculation of the HALP score at any of the predefined time points (preoperative, postoperative day 1, or postoperative day 7).
- •Incomplete clinical or follow-up data regarding postoperative outcomes.
研究组 & 干预措施
Patients Undergoing Esophagectomy
Adult patients who underwent elective esophagectomy for esophageal cancer at a single tertiary referral center between June 2020 and March 2025. Patients with available perioperative laboratory measurements required for calculation of the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score before surgery and on postoperative days 1 and 7 were included in the retrospective cohort.
干预措施: Perioperative HALP Score Assessment (Other)
结局指标
主要结局
Incidence of postoperative complications
时间窗: Baseline (preoperative), postoperative day 1, and postoperative day 7 for HALP measurements; Postoperative complications - from the day of surgery to hospital discharge, with follow-up extending up to 101 days in the patient with the longest stay
Incidence and severity of postoperative complications following esophagectomy, classified according to the Clavien-Dindo classification. HALP scores were measured at baseline (preoperatively) and on postoperative days 1 and 7 and were evaluated as predictors of postoperative complications. Postoperative complications were assessed from the day of surgery through hospital discharge.
次要结局
- Incidence of major postoperative complications (Clavien-Dindo grade III or higher)(Baseline (preoperative), postoperative day 1, and postoperative day 7 for HALP measurements; Postoperative complications - from the day of surgery to hospital discharge, with follow-up extending up to 101 days in the patient with the longest stay)
- Incidence of unplanned intensive care unit (ICU) readmission(From the day of surgery to hospital discharge, with follow-up extending up to 101 days in the patient with the longest stay)
- Perioperative changes in HALP score(Baseline (preoperative), postoperative day 1, and postoperative day 7 for HALP measurements)
研究者
Taner Abdullah
Assoc. Prof.
Istanbul Saglik Bilimleri University