Value of Myocardial Work for Prediction of Left Ventricular Remodeling in Patients With ST-Elevation Myocardial Infarction Treated by Primary Percutaneous Intervention
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 98
- 试验地点
- 1
- 主要终点
- Delta-work efficiency by echocardiography
研究概览
简要总结
The study intends to investigate the alteration of regional myocardial work in patients with acute anterior myocardial infarction underwent primary percutaneous coronary intervention (PCI), and compare the distribution of regional myocardial work in patients with/without early remodeling at acute phase and 3-month follow-up.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Anterior myocardial infarct (anterior myocardial infarct is defined as persistent chest pain for 30 mins at least, with ST-segment elevation of at least 0.2 mV in two or more contiguous precordial leads) within 12 hours after onsets of symptom;
- •Left anterior descending (LAD) as culprit vessel, with TIMI 0-1 grade.
排除标准
- •significant valvular disease;
- •cardiomyopathy; l
- •left bundle branch block;
- •atrial fibrillation;
- •previous myocardial infarction (MI);
- •history of cardiac surgery;
- •pacemaker implantation.
结局指标
主要结局
Delta-work efficiency by echocardiography
时间窗: 24-72 hours after PCI
A novel tool for non-invasive myocardial work(MW) assessment has been introduced to evaluate myocardial performance.MW was calculated as a function of time through a combination of LV global longitudinal strain(GLS) data and an estimated LV pressure curves. Work efficiency (WE) was calculated from the ratio of the constructive work to the sum of constructive and wasted work, expressed as a percentage.The values of culprit regional WE was expressed as WE-LAD.The values of non-culprit regional WE was expressed as WE-nonLAD.The absolute differences of the WE was calculated as the values of non-culprit regional WE minus the values of culprit regional WE, and noted as delta-WE.
次要结局
- Work index-LAD(24-72 hours, 3-month after PCI)
- Constructive work-LAD(24-72 hours, 3-month after PCI)
- Global constructive work by echocardiography(24-72 hours, 3-month after PCI)
- Work efficiency-LAD(24-72 hours, 3-month after PCI)
- Global work index by echocardiography(24-72 hours, 3-month after PCI)
- Global work efficiency by echocardiography(24-72 hours, 3-month after PCI)