Myocardial Work for Prediction of Left Ventricular Remodeling in Patients With STEMI

Completed

• Conditions: ST-Segment Elevated Myocardial Infarction

• Registration Number: NCT05107102
• Lead Sponsor: RenJi Hospital

Brief Summary

The study intends to investigate the alteration of regional myocardial work in patients with acute anterior myocardial infarction underwent primary percutaneous coronary intervention (PCI), and compare the distribution of regional myocardial work in patients with/without early remodeling at acute phase and 3-month follow-up.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-09-10
• Primary Completion: 2021-05-24
• Study Completion: 2021-08-30
• Status Verified: 2021-10
• Study First Submitted: 2021-10-24
• Study First Submitted QC: 2021-10-24
• Last Update Submitted: 2021-10-24
• Study First Posted: 2021-11-04
• Last Update Posted: 2021-11-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

• Anterior myocardial infarct (anterior myocardial infarct is defined as persistent chest pain for 30 mins at least, with ST-segment elevation of at least 0.2 mV in two or more contiguous precordial leads) within 12 hours after onsets of symptom;
• Left anterior descending (LAD) as culprit vessel, with TIMI 0-1 grade.

Exclusion Criteria

• significant valvular disease;
• cardiomyopathy; l
• left bundle branch block;
• atrial fibrillation;
• previous myocardial infarction (MI);
• history of cardiac surgery;
• pacemaker implantation.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Delta-work efficiency by echocardiography	24-72 hours after PCI	A novel tool for non-invasive myocardial work(MW) assessment has been introduced to evaluate myocardial performance.MW was calculated as a function of time through a combination of LV global longitudinal strain(GLS) data and an estimated LV pressure curves. Work efficiency (WE) was calculated from the ratio of the constructive work to the sum of constructive and wasted work, expressed as a percentage.The values of culprit regional WE was expressed as WE-LAD.The values of non-culprit regional WE was expressed as WE-nonLAD.The absolute differences of the WE was calculated as the values of non-culprit regional WE minus the values of culprit regional WE, and noted as delta-WE.

Secondary Outcome Measures

Name	Time	Method
Work index-LAD	24-72 hours, 3-month after PCI	Work index in left anterior descending(LAD) territory.
Constructive work-LAD	24-72 hours, 3-month after PCI	constructive work in left anterior descending(LAD) territory.
Global constructive work by echocardiography	24-72 hours, 3-month after PCI	Global constructive work (GCW) was defined as work contributing to LV ejection performed during shortening in systole and work performed during lengthening in isovolumic relaxation.
Work efficiency-LAD	24-72 hours, 3-month after PCI	Work efficiency in left anterior descending(LAD) territory.
Global work index by echocardiography	24-72 hours, 3-month after PCI	Global work index (GWI) is classified as total work within the area of the LV pressure-strain loop calculated from mitral valve closure to mitral valve opening.
Global work efficiency by echocardiography	24-72 hours, 3-month after PCI	Global work efficiency (GWE) was calculated from the ratio of the constructive work to the sum of constructive and wasted work, expressed as a percentage.

Trial Locations

Locations (1)

Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University; 🇨🇳 Shanghai, Shanghai, China