Anemia in Chronic Heart Failure due to circulation factors
Recruiting
- Conditions
- Anemia1000208610019280
- Registration Number
- NL-OMON29720
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
a. Male or female
b. Between 50-90 years of age
c. Willing to provide written informed consent
Exclusion Criteria
f. Unstable medical condition
g. Presence of other serious medical conditions
h. Renal failure (kreatinin > 150 µmol/l)
i. Concomitant inflammatory or malignant disease
j. *Wilsonbekwaamheid*
k. Chronic steroid use
l. Recent blood transfusion
m. Currently receiving EPO-treatment
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Difference in proliferation, G2/G0 ratio and numbers of apoptotic cells after<br /><br>EPO-stimulation of UT7-EPO cells after 3 days in culture.</p><br>
- Secondary Outcome Measures
Name Time Method <p>•Difference between anaemic and non-anaemic CHF patients in plasma<br /><br>ACE-activity, Ac-SDKP, EPO, high-sensitivity CRP, IFN-gamma, IL-1, and<br /><br>TNF-alpha levels.<br /><br>•Correlation between UT7-EPO cell proliferation and plasma ACE-activity,<br /><br>Ac-SDKP, EPO, high-sensitivity CRP, IFN-gamma, IL-1, and TNF-alpha levels.<br /><br>•Difference in proliferation between untreated and inhibitory antibody<br /><br>pre-treated serum</p><br>