The McGill experience with Chronic Cough Treatment: A Phase 2 Pilot Study

McGill University Health Centre0 个研究点目标入组 100 人开始时间: 2015年1月6日最近更新: 2019年11月25日

适应症

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•Included patients will be patients having had cough symptoms for at least 3 months (chronic cough), and that have already been worked up by respirologists to rule out other etiologies of cough. These patients will have failed all other medical therapies: inhaled corticosteroids and single dose of antireflux medication.

•1. Patients without cough symptoms for over 3 months
•2. Patients that have not been worked up by a respirologist and who have not attempted inhaled corticosteroids or antireflux medication
•3. Patients who have been taking over the counter (OTC) antitussives, or angiotensin converting enzymes inhibitors medication
•4. Patients who have been taking antibiotics in the last month for a respiratory tract infection
•5. Patients who are smokers (both smoking and recent respiratory tract infection could confound our results)
•6. Patients who are pregnant or breast feeding
•7. Patients with abnormal hepatic or kidney function tests (creatinine over 100, ALT over 36 U/L, AST over 35 U/L, total bilirubin over 26 mmol/L)
•8. Patients with abnormalities on the electrocardiogram that have not been cleared by a cardiologist
•9. Patients with significant cardiac, renal, hepatic, epileptic, hematologic antecedents
•10. Patients taking anticholinergic or sympathomimetic medications
•11. Patients above the age of 70

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