Preservation of microcirculatory perfusion after pulsatile cardiopulmonary bypass: the role of prothrombogenic processes and the endothelium.
Completed
- Conditions
- bypass operationcardiac surgery10011082
- Registration Number
- NL-OMON36700
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 48
Inclusion Criteria
Patients undergoing coronary artery bypass graft (CABG) surgery
Age 40-85 years
Informed consent
Exclusion Criteria
Re-operations and emergency operations
Patients with insulin-dependent diabetes mellitus
Patients with a body mass index (BMI) > 35 kg/m²
Patients with anemia (Hb <5.5 mmol/l)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Change in microcirculatory perfusion, sublingual erythrocyte velocity,<br /><br>capillary diameter and capillary density.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Change in fibrin network formation, platelet aggregation, endothelial function,<br /><br>fybrinolysis and red blood cell deformability.</p><br>