Prevention of pain due to propofol injection: A comparative study of lignocaine, dexmedetomidine and placebo.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Incidence and severity of pain due to propofol injection.
研究概览
简要总结
Aims & objectives: this study was designed to compare and evaluate efficacy of lignocaine, dexmedetomidine & placebo in preventing pain due to propofol injection.
Methods: 90 adults were assigned into three groups.With aim of keeping the drug in the vein,forearm was squeezed with tourniquet upto 70 mmhg.Group 1(n=30) received 0.25microgm/kg of dexmedetomidine, group 2(n=30) 0.5 mg/kg of lignocane diluted in 5ml of NS & group 3(n=30) 5ml of NS followed by an injection of proposal from same vein after releasing the occlusion. Pain assessment was made immediately after propofol injection using McCrirrik & Hunter Scale.
Result: the number of patient who suffered from any degree of pain was low in group1 & 2
Discussion: Lidocaine and dexmedetomidine significantly reduced the incidence and severity of propofol injection pain more than placebo ( p< 0.001). The efficacy of dexmedetomidine in alleviating the pain on injection of propofol is no different from lidocaine.
Conclusion: Dexmedetomidine pretreatment may be used to reduce the incidence of pain on injection of propofol, with added advantage of sparing effect on the requirement of analgesics and sedatives, better hemodynamics profile and anti- shivering action
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 17.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Written informed consent.
- •Patients of either sex.
- •Aged between 17 -70 years Belonging to ASA GRADE 1 and 2( Based on the physical status,the patients are classified into categories by American Society of Anaesthesiologists) Requiring standard General Anaesthesia (G.A).
排除标准
- •Concomitant analgesic or sedative medication, patients requiring rapid sequence induction, anticipated difficulty venous access, difficulty in communication Known sensitivity to lignocaine or dexmedetomidine Conditions where use of lignocaine and dexmedetomidine may be harmful Presence of infection on the dorsum of hand.
结局指标
主要结局
Incidence and severity of pain due to propofol injection.
时间窗: AT the time of induction of anesthesia.
Effect of lignocaine, dexmedetomidine and placebo prtreatment in attenuating this pain.
时间窗: AT the time of induction of anesthesia.
次要结局
- To assess the recall of pain in patients after the surgery.(In the recovery room after the surgery)