Distal radioulnar joint cartilage quantification at ultra high field 7T MRI

Completed

• Conditions: gewricht en kraakbeen; cartilage damage; osteoarthritis

• Registration Number: NL-OMON40310
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Volunteers:
Adults (> 18 years old) and mentally competent.
No ulnar sided wrist pain, previous surgery or trauma of the wrist.;Patients:
Adults (>18 years old) and mentally competent.
Symptomatic DRUJ complaints regarding cartilage damage, OA or pre-OA.
Patients that will undergo DRUJ replacement surgery (ulnar head prosthesis) or have DRUJ instability.

Exclusion Criteria

o Impossibility to undergo MRI (claustrophobia, implants or metal objects in or around the body that are not accepted for ultra high field strength MRI)
o <18 years old and mentally incompetent
o Previous wrist surgery
o Previous trauma (applicable to the volunteers group)
o Pregnancy

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameter/endpoint is the DRUJ cartilage quality. Healthy cartilage<br /><br>and injured cartilage will be compared on the 7T MR images, descriptively for<br /><br>morphology and quantitatively for composition. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Investigate the trend in correlation of qualitative imaging to:<br /><br>- Pain.<br /><br>- Disability.<br /><br>- Range of motion.<br /><br>- Healthy versus OA patients.<br /><br>- Assess reproducibility in obtaining the quantified imaging parameters.</p><br>