Echocardiographic study of Left Ventricular diastolic dysfunction in Type 2 Diabetes Mellitus patients and correlation with hba1c levels.
Trial Snapshot
- Phase
- Phase 1
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Diabetes mellitus type 2 is associated with left ventricular diastolic dysfunction.
Study Overview
Brief Summary
This study aims to find out the incidence of Left ventricular diastolic dysfunction in patients with Diabetes mellitus type 2. Patients can be newly diagnosed or have a history of DMt2. At presentation all the participants will be tested with serum HbA1c levels which gives us an idea of blood sugar control for the past 3 months. Then the patient will go on to have a 2d echocardiography done, where in parameters for diastolic dysfunction will be measured. Presence or absence of Diastolic dysfunction will be determined by recommendations made by American society of Echocardiography and European Association of cardiovascular Imaging in 2016. The diastolic dysfunction if present will be graded as mild , moderate or Severe and compared to the earlier HbA1c levels. There will be another comparison of severity of diastolic dysfunction between smoking and non smoking Diabetic patients.
Study Design
- Study Type
- Interventional
- Allocation
- Not Applicable
- Masking
- Not Applicable
Eligibility Criteria
- Ages
- 50.00 Year(s) to 99.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients with DM type 2 .Cases were selected as per the diagnostic criteria laid down by the American Diabetes Association.
- •Fasting blood glucose (FBS) of 126 mg/dl or higher or a 2-hr postprandial blood glucose (PPBS) level of 200 mg/dl or higher during a 75-gm oral glucose tolerance test or random plasma glucose of 200 mg/dl or higher in a patient with symptoms of hyperglycemia or HbA1c 6.5% or higher.
Exclusion Criteria
- •Patients with systemic hypertension, coronary artery disease, ischemic heart disease, cardiomyopathy, valvular disorders, connective tissue disorder, CLD, CKD and thyroid dysfunction.
Outcomes
Primary Outcomes
Diabetes mellitus type 2 is associated with left ventricular diastolic dysfunction.
Time Frame: Baseline
Secondary Outcomes
- Smoking worsens diastolic dysfunction in diabetic patients(Baseline)