LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN PATIENTS OF ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- To evaluate the prevalence of ventricular systolic dysfunction in patients of acute exacerbation of chronic obstructive pulmonary disease
研究概览
简要总结
Purpose of trial - To evaluate prevalence of left ventricular systolic dysfunction in patients with acute exacerbation of COPD
Objectives -
Primary Objective-To evaluate the prevalence of left ventricular systolic dysfunction in patients with acute exacerbation of COPD
Secondary Objective - To determine correlation between NTpro BNP levels and left ventricular systolic dysfunction in patients with acute exacerbation of COPD
Some Major findings and references-
In a research study conducted by Winther et al. evaluating the diagnostic and prognostic significance of NT pro BNP in acute exacerbation of COPD and heart failure it was found to be a good marker to separate dyspnoea due to acute heart failure and not due to heart failure.
A study by Chang et al. analysed cardiac biomarkers in predicting mortality in acute exacerbation of COPD
In a study by Abroug et al. showed 31 % patients admitted in ICU for severe AE COPD had associated left heart dysfunction. NT pro BNP levels performed better to rule out than to rule in AECOPD with left dysfunction.An NT proBNp level of 1000pg/ml or less was the optimal cutoff to rule out an association of LV dysfunction with sensitivity of 94 % negative predictive value 94% and negative likelihood ratio of 0.08.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with age 18 years or more with acute exacerbation of chronic obstructive pulmonary disease and ability to undergo echocardiography.
排除标准
- •Pulmonary embolism Pneumonia Pneumothorax Renal Dysfunction Acute coronary event Valvular Heart Disease Hepatic Dysfunction Known case of Dilated Cardiomyopathy.
结局指标
主要结局
To evaluate the prevalence of ventricular systolic dysfunction in patients of acute exacerbation of chronic obstructive pulmonary disease
时间窗: Less than or equal to one year
次要结局
- To determine the correlation between NTproBNP levels and Left ventricular systolic dysfunction in acute exacerbation of COPD(Less than or equal to one year)