Assessment of latent left ventricular dysfunction in asymptomatic severe valvular regurgitatio

Not Applicable

Recruiting

• Conditions: Mitral regurgitation; Cardiovascular - Normal development and function of the cardiovascular system

• Registration Number: ACTRN12606000026527
• Lead Sponsor: ational Heart Foundation

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-01-20
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

Severe asymptomatic/minimally symptomatic MR.

Exclusion Criteria

Patients with known coronary artery disease, previous cardiac surgery, greater than mild mitral stenosis and significant aortic valve disease (stenosis or regurgitation) and suboptimal images.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Predict latent LV dysfunction (loss of contractile reserve with isotonic exercise) with myocardial strain and cyclic variation of integrated backscatter (IB)[]

Secondary Outcome Measures

Name	Time	Method
Correlate strain and IB with the presence and severity of myocardial fibrosis, assessed with fine needle biopsy.[];Predict clinical outcome (preservation of LV function, exercise capacity and quality of life) with strain and IB.[]