Left Ventricular Dysfunction in Critically Ill Patients

Completed

• Conditions: Left Ventricular Dysfunction; Takotsubo Cardiomyopathy; Critically Ill; Cardiomyopathies; Acute Coronary Syndrome

• Registration Number: NCT03787810
• Lead Sponsor: Sahlgrenska University Hospital, Sweden

Brief Summary

Left ventricular dysfunction is common in the critically ill. The aim of this study is to assess the incidence and prognosis of left ventricular dysfunction in critically ill patients.

Detailed Description

Left ventricular dysfunction is common in the critically ill. A number of conditions can cause left ventricular dysfunction including myocardial infarction, septic cardiomyopathy, post resuscitation syndrome, takotsubo syndrome etc. A number of studies have assessed cardiac dysfunction in specific conditions (e.g. sepsis, cardiac arrest) but only a few studies have assessed cardiac dysfunction in a general ICU-population. The study will focus on diagnostics of the different types of cardiomyopathy and differentiating between ischemic and non-ischemic left ventricular dysfunction in a general ICU population. The aim of this study is to assess the incidence and prognosis of the different types of left ventricular dysfunction in critically ill patients. Our hypothesis is that left ventricular dysfunction is common in the critically ill and is associated with an increased risk of short-term death.

Study Timeline

• Study Start: 2018-05-28
• Study First Submitted: 2018-12-23
• Study First Submitted QC: 2018-12-23
• Study First Posted: 2018-12-26
• Primary Completion: 2019-02-20
• Status Verified: 2019-09
• Study Completion: 2020-02-20
• Last Update Submitted: 2020-04-21
• Last Update Posted: 2020-04-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 428

Inclusion Criteria

• Admitted within 24 hours to the ICU
• Dysfunction of at least one organ system, defined as at least +1 point in SOFA-score.

Exclusion Criteria

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mortality	30 days	All cause mortality after admission to the ICU

Trial Locations

Locations (1)

Sahlgrenska University Hospital; 🇸🇪 Gothenburg, Västra Götalandsregionen, Sweden