The Evaluation of Left Ventricular Systolic Function in Different Types of Ischemic Heart Disease

Completed

• Conditions: Coronary Microvascular Dysfunction; Obstructive Coronary Heart Disease
• Interventions: Diagnostic Test: Two dimensional speckle tracking imaging

• Registration Number: NCT04959357
• Lead Sponsor: Peking University Third Hospital

Brief Summary

The study was designed to evaluate the left ventricular longitudinal strain and strain rate assessed by 2D-STI in patients with coronary microvascular dysfunction (CMD) or obstructive coronary artery disease (CAD) , to investigate the effect of different types of ischemic heart disease on the LV systolic function, and to explore the value of LS on the diagnosis of coronary microvascular dysfunction.

Detailed Description

A total of 175 patients with chest pain, without wall motion abnormality and without significant coronary artery stenosis (\<50%) assessed by coronary angiography or coronary computed tomography were enrolled from July 2011 to December 2017. Coronary flow reserve (CFR) of these patients were detected by transthoracic Doppler echocardiography. The patients were divided into coronary microvascular dysfunction group ( CFR≤2.5, n=67) and control group (CFR\>2.5, n=108). At the same time, 67 age-matched patients with any major coronary arteries stenosis≥50% and without wall motion abnormality were involved into the obstructive coronary artery disease group. Parameters of global longitudinal strain (LS) and strain rate, subendocardial LS and subepicardial LS were quantified by 2D-STI, the differences of these parameters among three groups were analyzed，correlation analysis、univariate and multivariate analysis and receiver operating characteristic curve were used.

Study Timeline

• Study Start: 2018-03-15
• Primary Completion: 2018-10-30
• Study Completion: 2018-12-30
• Study First Submitted: 2021-06-27
• Status Verified: 2021-07
• Study First Submitted QC: 2021-07-12
• Last Update Submitted: 2021-07-12
• Study First Posted: 2021-07-13
• Last Update Posted: 2021-07-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 242

Inclusion Criteria

• age from 18-85 years

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Exclusion Criteria

• patients with history of myocardial infarction or abnormal wall motion suggested by conventional echocardiography
• patients with acute heart failure, chronic heart failure or LVEF values less than 50%
• patients with congenital heart disease, severe valvular disease, severe bradycardia, high atrioventricular block and atrial fibrillation
• patients who did not store ultrasound images or whose ultrasound images were unclear
• patients who had incomplete clinical data

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
coronary microvascular dysfunction group	Two dimensional speckle tracking imaging	-
control group	Two dimensional speckle tracking imaging	-
obstructive coronary artery disease	Two dimensional speckle tracking imaging	-

Primary Outcome Measures

Name	Time	Method
global longitudinal strain	15/3/2018-30/12/2018	global longitudinal strain of CMD group and obstructive CAD group

Trial Locations

Locations (1)

Department of Cardiology, Peking University Third Hospital, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides; 🇨🇳 Beijing, Beijing, China