Assessing acute and late developing heart function in patients with sepsis and septic shock with cardiac ultrasound
- Conditions
- eft ventricular function in septic shockCirculatory SystemLeft ventricular function in septic shock
- Registration Number
- ISRCTN13837507
- Lead Sponsor
- Portsmouth Hospitals NHS Trust
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 118
1. Aged 18-85 years inclusive
2. Sepsis or septic shock (defined by Third International Consensus Definitions for Sepsis and Septic Shock)
3. Admission to the Intensive Care Unit (ICU)
4. Consent to inclusion or favourable opinion for inclusion from consultee
1. Pregnancy or complications thereof
2. End-Stage Renal Failure (ESRF) requiring dialysis, or Chronic Kidney Disease (CKD) with eGFR <30 ml/min
3. Cardiac transplant recipient
4. Uncorrected valvular dysfunction (graded as moderate or severe)
5. Known structural heart disease
6. Pre-existing cardiomyopathy with bundle block on electrocardiogram (ECG)
7. Previous cardiac valve replacement
8. Post-operative within last 7 days
9. Atrial fibrillation/flutter or frequent ventricular ectopic beats during image acquisition
10. Death likely within 24 h in the opinion of the assessing clinician
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Left ventricular function measured using:<br>1.1. Echocardiography: two-dimensional ejection fraction calculation (2D EF), three-dimensional ejection fraction (3D EF), and global longitudinal strain (GLS), at 24 h, 72 h, 30 days, and 90 days<br>1.2. Peripheral venous blood tests to identify troponin (high sensitivity assay- HS TROP), and B-type natriuretic peptides (BNP) at 24 h, 30 days, and 90 days
- Secondary Outcome Measures
Name Time Method There are no secondary outcome measures