Aromatherapy Treatment With Lavender Essential Oil to Reduce Post-Operative Nausea and Vomiting (PONV)

Not Applicable

Active, not recruiting

• Conditions: PONV

• Registration Number: NCT07176676
• Lead Sponsor: Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria

Brief Summary

The aim of this study is to evaluate the effectiveness of aromatherapy through the use of inhaled Lavender oil in reducing patients' nausea during the post-operative period.

Detailed Description

To evaluate the effectiveness of inhaling Lavender Angustifolia essential oil in reducing nausea after abdominal, vascular, neurosurgical and gynaecological surgery under general anaesthesia during the 24-hour postoperative period.

Secondary objective

* To detect the number of antiemetic administrations in the experimental arm compared to the control arm

* To measure the patient satisfaction of patients in the experimental group with the Lavender essential oil aromatherapy intervention at hospital discharge Primary endpoint Reduction of nausea by at least 10% compared to treatment with standard care, as assessed by the NRS (Numerical Rating Scale).

Study Timeline

• Study First Submitted: 2022-07-19
• Study Start: 2022-11-15
• Primary Completion: 2024-12-31
• Status Verified: 2025-09
• Study First Submitted QC: 2025-09-09
• Last Update Submitted: 2025-09-09
• Study First Posted: 2025-09-16
• Last Update Posted: 2025-09-16
• Study Completion: 2025-12-15

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 128

Inclusion Criteria

• Patients who sign an informed consent

  • Patients who have undergone anesthesiological examination
  • Patients undergoing general anaesthesia
  • Clinically stable patients
  • Patients with nausea scores detected with NRS>0
  • Patients admitted undergoing surgery in the Complex and/or Simple Structures listed below:
  • SC of Neurosurgery, undergoing spinal surgery
  • SC of General Surgery, undergoing surgery on one of the organs of the abdominal cavity
  • SC of Vascular Surgery, undergoing traditional surgical repair or endovascular procedure of abdominal aortic aneurysm. Sclerotherapy (to heal varicose veins) venous stripping (removal of a vein segment in the treatment of varicose veins) laser treatment
  • SS of Gynaecological Surgery, undergoing operations on the organs of the female genital apparatus.

Exclusion Criteria

Patients with ongoing relevant cognitive impairment (Six Item Screener score <4)

• Patients with allergies or sensitivities to lavender essential oils
• Patients with asthma, COPD, Chronic Bronchitis, Obstructive Sleep Apnea
• Patients with changes in sense of smell

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
To evaluate the effectiveness of administering Lavender Angustifolia essential oil by inhalation in reducing nausea after abdominal, vascular, neurosurgical and gynaecological surgery under general anaesthesia during the 24-hour postoperative period	during the 24-hour post-operative period	To reduce nausea after abdominal, vascular, neurosurgical and gynaecological surgery under general anaesthesia during the 24-hour postoperative period.; Endpoint Reduction of nausea by at least 10% compared to treatment with standard care, as assessed by the NRS (Numerical Rating Scale).

Secondary Outcome Measures

Name	Time	Method
To evaluate the effectiveness of administering Lavender Angustifolia essential oil by inhalation in reducing nausea after abdominal, vascular, neurosurgical and gynaecological surgery under general anaesthesia during the 24-hour postoperative period	during the 24-hour postoperative period	To measure the number of antiemetic administrations in the experimental arm compared to the control arm
o evaluate the effectiveness of administering Lavender Angustifolia essential oil by inhalation in reducing nausea after abdominal, vascular, neurosurgical and gynaecological surgery under general anaesthesia during the 24-hour postoperative period	during the 24-hour postoperative period	To measure the patient satisfaction of the patients in the experimental group regarding the aromatherapy intervention with Lavender essential oil at hospital discharge

Trial Locations

Locations (1)

Clinical Trial Center; 🇮🇹 Alessandria, Italy, Italy