Effect of adding ketamine infusion to propofol sedation on hemodynamic changes and recovery in patients undergoing elective lower limb surgery under spinal anaesthesia
Phase 4
Completed
- Conditions
- sedation for elective lower limb surgeryAnaesthesiology - Anaesthetics
- Registration Number
- ACTRN12615000372583
- Lead Sponsor
- Aysu Hayriye Tezcan
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 61
Inclusion Criteria
25-80 years old
Both gender
Candidate of elective lower limb surgery
Do not have contraindications for spinal anesthesia
Exclusion Criteria
Patients with a allergic reaction to propofol or ketamine, obesity (BMI greater than or equal to 35) , uncontrolled hypertension ( greater than 170/100mmHg), clinically significant cardiac, pulmonary, hepatic, renal dysfunction, psychiatric disorders, neurologic impairment were exluded from study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To observe difference in terms of hemodymanic parameters which were heart rate with electrocardiogram, noninvasive systolic, diastolic, mean blood pressure, peripheral oxygen saturation with pulse oxymetry. <br>(composite outcome)[All measurements done every 5 minutes during surgery.];Recovery profile assessed with mini mentel state examination[MMSE done first preoperatively and secondly thirty minutes after the sedation ending.]
- Secondary Outcome Measures
Name Time Method Side effects of ketamine infusion like agitation, vomiting, emergence reactions.[During sedation and in thirty minutes of the recovery period];Patient satisfaction were evaluated postoperatively[Postoperative questionnaire administered post-operatively on a three-point scale (1 = bad, 2 = borderline 3 = good)];Surgeon satisfaction were evaluated postoperatively[Postoperative questionnaire administered post-operatively on a three-point scale (1 = bad, 2 = borderline 3 = good)]