Nutritional Aspects of Rett Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
研究概览
简要总结
OBJECTIVES: I. Determine dietary macronutrient intake in children with Rett syndrome and in healthy controls.
II. Measure sleeping and awake metabolic rates in various positions, i.e., reclining, sitting, and standing, by whole-room indirect calorimetry and isotope dilution.
III. Quantify activity patterns by time-motion studies using 24-hour activity records and 12-hour videotaping.
IV. Correlate 24-hour activity patterns with 24-hour heart rate telemetry and short-term oxygen consumption.
V. Estimate 24-hour fecal and urinary energy losses. VI. Determine body composition by clinical anthropometry, whole-body potassium counting, and total-body electrical conductance.
VII. Calculate apparent energy needs based on measurement of energy intake and expenditure.
详细描述
PROTOCOL OUTLINE:
All participants undergo extensive nutritional and metabolic assessment with body composition evaluation. Studies include macronutrient intake, body fat, lean muscle mass, metabolic rate, and time-action studies; and 24-hour cardiac telemetry. Rett syndrome girls also receive a hemogram and hand x-ray.
研究设计
- 研究类型
- Interventional
- 主要目的
- Diagnostic
入排标准
- 年龄范围
- 5 Years 至 18 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •PROTOCOL ENTRY CRITERIA:
- •Patients aged 5 to 18 with Rett syndrome Able to sleep and awaken alone
排除标准
- 未提供