Nutritional Aspects of Rett Syndrome
- Conditions
- Rett Syndrome
- Registration Number
- NCT00004656
- Lead Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Brief Summary
OBJECTIVES: I. Determine dietary macronutrient intake in children with Rett syndrome and in healthy controls.
II. Measure sleeping and awake metabolic rates in various positions, i.e., reclining, sitting, and standing, by whole-room indirect calorimetry and isotope dilution.
III. Quantify activity patterns by time-motion studies using 24-hour activity records and 12-hour videotaping.
IV. Correlate 24-hour activity patterns with 24-hour heart rate telemetry and short-term oxygen consumption.
V. Estimate 24-hour fecal and urinary energy losses. VI. Determine body composition by clinical anthropometry, whole-body potassium counting, and total-body electrical conductance.
VII. Calculate apparent energy needs based on measurement of energy intake and expenditure.
- Detailed Description
PROTOCOL OUTLINE:
All participants undergo extensive nutritional and metabolic assessment with body composition evaluation. Studies include macronutrient intake, body fat, lean muscle mass, metabolic rate, and time-action studies; and 24-hour cardiac telemetry. Rett syndrome girls also receive a hemogram and hand x-ray.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- Not specified
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method