Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)

Completed

• Conditions: CADASIL

• Registration Number: NCT02071784
• Lead Sponsor: Institut National de la Santé Et de la Recherche Médicale, France

Brief Summary

The aim of this study is to investigate using fMRI methods, EEG and dedicated mathematical models, the potential alterations of neurovascular coupling in CADASIL.

Detailed Description

Comparison study of parameters derived from mathematical models of neurovascular coupling and obtained using fMRI (Bold signal, ASL and EEG).

Study Timeline

• Study First Submitted: 2014-02-24
• Study First Submitted QC: 2014-02-25
• Study First Posted: 2014-02-26
• Study Start: 2014-07-08
• Primary Completion: 2016-10-24
• Study Completion: 2016-10-24
• Status Verified: 2021-08
• Last Update Submitted: 2021-08-24
• Last Update Posted: 2021-08-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• CADASIL group: typical NOTCH3 mutation, age less than 60 years, rankin score at 0-1, active social insurance

Exclusion Criteria

• MRI contra-indications and use of any treatment known to interfere with neurovascular coupling, pregnancy, lack of informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
model-derived parameters of neurovascular coupling	one time point

Trial Locations

Locations (1)

CENIR, Hopital Pitié Salpetriere; 🇫🇷 Paris, France