2025-523589-26-00招募中4 期
Infusion of Furosemide to Improve Diuretic Efficiency in Acute Heart Failure (INFUSE-AHF)
Region Midtjylland7 个研究点 分布在 1 个国家目标入组 436 人开始时间: 2026年5月1日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 发起方
- 入组人数
- 436
- 试验地点
- 7
- 主要终点
- Net weight loss 3 days (≈72 hours) after randomisation
研究概览
简要总结
To determine if there is a difference in the diuretic treatment effect in acute heart failure between intravenous administration of furosemide by either continuous infusion preceded by a loading dose or bolus injections three times a day.
研究设计
- 分配方式
- Na
- 主要目的
- Follow-up phase
- 盲法
- None
入排标准
- 年龄范围
- 18 years 至 65+ years（65+ Years, 18-64 Years）
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of acute heart failure with volume overload
- •≥ 1 sign of volume overload
- •Anticipated intravenous furosemide ≥ 3 days
- •Age ≥ 18 years
排除标准
- •Patient requiring treatment with inotropes or vasopressors
- •Current or planned use of renal replacement therapy or ultrafiltration
- •Patient with a renal transplant
- •Patients who are pregnant or breastfeeding
- •Severe hypokalaemia (<2.5 mmol/L) or severe hyponatremia (<125 mmol/L)
- •Allergy to furosemide and its components
研究组 & 干预措施
FUROSEMIDE
Test
干预措施: FUROSEMIDE (Drug)
结局指标
主要结局
Net weight loss 3 days (≈72 hours) after randomisation
Net weight loss 3 days (≈72 hours) after randomisation
次要结局
- Net weight loss 2 days (≈48 hours) after randomisation
- Change in dyspnea on a Visual Analogue Scale 3 days (≈72 hours) after randomisation
- Days alive out-of-hospital to Day 30
- Length of stay
研究者
Esben Merrild
Scientific
Region Midtjylland
研究点 (7)
Loading locations...
相似试验
招募中
不适用
"Effect of Albumin Combined With Furosemide in Critically Ill Patients With Fluid Overload: Impact on Urine Output and Renal Function"NCT07417969Jose J Zaragoza, MD MSc56
招募中
不适用
Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical ProceduresNCT07348510Cairo University106
已完成
不适用
Comparison of the Effectiveness of Different Diuretic Therapies in the Management of Acute Heart FailureNCT07464249Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey50
已完成
不适用
Impact of Forced Diuresis on the Residual Fragment Rate After Flexible Ureteroscopy for Management of Renal StonesNCT07336485Ain Shams University200
招募中
4 期
Efficacy and safety trial of intraperitoneal furosemide in patients on peritoneal dialysis2024-519356-87-00Fundacion Para El Fomento De La Investigacion Sanitaria Y Biomedica De La Comunitat Valenciana37