Adaptive neuromodulation for movement disorders.

Completed

Conditions: dystonia
Parkinson's disease
10028037

Registration Number: NL-OMON42422

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 24

Inclusion Criteria

PD
- sound of mind
- eligible for battery replacement surgery
- ability to provide written informed consent
- ability to undergo testing in the OFF medication state - physical condition that enables 90 minutes of testing
Dystonia:
- sound of mind
- eligible for DBS surgery
- ability to provide written informed consent
- dystonia in at least one muscle that is suitable for prolonged EMG recording

Exclusion Criteria

all contra-indications that apply to normal DBS surgery (eg pregnancy, life expectancy of less than one year)
< 18 yo
other disorder that interferes with clinical assessment

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>PD<br /><br>clinical effect of aDBS compared placebo and cDBS based on blinded clinical<br /><br>ratings<br /><br><br /><br>dystonia:<br /><br>feasibility and tolerability of aDBS based on LFP low-frequency power</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>PD<br /><br>side effect profile of aDBS compared to cDBS and placebo<br /><br>energy consumption of aDBS compared to cDBS<br /><br><br /><br>dystonia:<br /><br>effect of aDBS on subcortico-muscular coherence and clinical ratings<br /><br>energy consumption of aDBS compared to cDBS</p><br>