comparision of efficacy of two medicines(dexmeditomidine and dexamethasone) when used with another medicine(ropivacaine)when given as injections at side of neck,surrounding the nerves of shoulder joint as pain relief measure during shoulder surgeries done through surgical instrument(arthroscope)
- Conditions
- Subluxation and dislocation of other and unspecified parts of shoulder girdle,
- Registration Number
- CTRI/2019/01/017082
- Lead Sponsor
- Dr Manasa S
- Brief Summary
Addition of adjuvant (opioids or non-opioids) with local anaesthetics in brachial plexus block is aimed at quicker onset, enhanced quality and duration of blockade. Dexmedetomidine is a selective alpha-2 adrenoreceptor agonist and Dexamethasone is a glucocorticoid.Studies prove that, both the drugs when added to local anaesthetics in regional nerve blocks ,they shorten the onset of action of block, prolong the duration of motor and sensory block as well as analgesia. It’s a known fact that dexmedetomidine causes bradycardia and hypotension when used in the
dose of 1 to 1.5 microgram per kg, which can be very difficult to treat. Also dexmedetomidine is
comparatively costlier than dexamethasone. But many previous studies done so far have shown that dexmedetomidine is very effective as an analgesic and also significantly prolongs the duration of sensory blockade when used as an adjuvant with local anaesthetics for peripheral nerve blocks. Hence this study is been done to compare the efficacy of dexmedetomidine and dexamethasone as adjuvants with 0.2% ropivacaine in arthroscopic shoulder surgeries.
**Detailed description of procedure / processes**:
All patients will be seen the day prior to surgery, assessed for suitability of inclusion in study. Informed consent will be taken. They will be premedicated and Standard guidelines for fasting will be followed. On the day of surgery, in the operation theatre, a suitable intravenous access will be obtained. Monitoring with pulse oximetry, noninvasive blood pressure monitor and five-lead electrocardiography will be commenced and note the baseline values. The patient will reassessed by consultant anaesthesiologist and he/she will administer ultrasound guided Interscalene block as per standard protocol in the department with the additive of his/her choice (either Dexmeditomedine or Dexamethasone).
The onset and duration of sensory loss and motor blockade will be noted.
Pre-operative, intra-operative and post-operative data will be collected and analyzed in the study. No other intervention will be done.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
American society of Anaesthesiologist physical status 1 or 2, patients undergoing elective arthroscopic shoulder surgery under interscalene blockwith 0.2% ropivacaine+1microgram/kg of dexmeditomidine or 100 microgram/kg of dexamethasone+General Anaesthesi as per standard protocol.
patient refusal,bleeding disorders,local infections,pregnsnt women,local anaesthetics allergy,seizure disorders.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method duration of sensory and motor blockade duration of sensory and motor blockade
- Secondary Outcome Measures
Name Time Method need for rescue analgesia IN POST OPERATIVE PERIOD ,WITHIN 24HOURS
Trial Locations
- Locations (1)
KASTURBA MEDICAL COLLEGE ,MANIPAL
🇮🇳Udupi, KARNATAKA, India
KASTURBA MEDICAL COLLEGE ,MANIPAL🇮🇳Udupi, KARNATAKA, IndiaDR MANASA SPrincipal investigator9591211323manassubindu28@gmail.com