Endocan Predictive Value in Postcardiac Surgery Acute Respiratory Failure. The ENDOLUNG Study
试验速览
- 阶段
- 不适用
- 入组人数
- 150
- 主要终点
- Changes of Endocan blood levels after cardiac surgery and its correlation with postoperative pulmonary failure
研究概览
简要总结
According to literature data, Endocan can detect the onset of respiratory failure. The investigators aim to prove its value also for cardiac surgery patients.
详细描述
Endocan is an endothelium derived soluble dermatan sulfate proteoglycan. Literature data shows that alterate levels of its blood concentration correlate with the onset of pulmonary failure in patients with major trauma and septic shock.
In cardiac surgery respiratory failure and infections are threatening complications leading to mortality rates up to 80%. A rapid diagnosis and treatment of this pathology is crucial to improve the clinical outcome.
Unfortunately specific data for the efficacy of Endocan predictive value in cardiac surgery patients are not available.
The investigators aim to determinate if Endocan can be a helpful tool to identify patients developing acute respiratory failure after cardiac surgery and anticipate specific treatment in order to improve survival.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Able to give written consent
- •Elective cardiac surgery
- •More than 18 years old
排除标准
- •Less than 18 years old
- •urgency / emergency cardiac surgery
- •pregnancy
- •unable to give written consent
- •oncologic patients
- •concomitant inflammatory or infective pulmonary disease
结局指标
主要结局
Changes of Endocan blood levels after cardiac surgery and its correlation with postoperative pulmonary failure
时间窗: from day -1 of the intervention to day 3, one blood sample per day
The investigators will enroll 150 patients undergoing elective cardiac surgery. Every participant will be prelevated of several blood samples following this time frame : day -1 from intervention, day 0 ( six hours after intervention), day 1 , day 2 , day 3. All patients will be observed to detect all infections, especially pulmonary ones, up to hospital discharge. Endocan blood levels of patients developing pulmonary failure and patients without postoperative respiratory insufficiency will be compared.
次要结局
未报告次要终点
研究者
Andrea PERROTTI
Medical Doctor
Centre Hospitalier Universitaire de Besancon