Noninvasive Dual-mode Stimulation Therapy for Neurorehabilitation in Post-stroke Cognitive Impairment
- Conditions
- Post-stroke Cognitive Impairment
- Interventions
- Device: High-frequency rTMS on left DLPFC+anodal tDCS on right DLPFCDevice: High-frequency rTMS on left DLPFC+cathodal tDCS on right DLPFCDevice: High-frequency rTMS on left DLPFC+sham tDCS on right DLPFC
- Registration Number
- NCT03647319
- Lead Sponsor
- Samsung Medical Center
- Brief Summary
Repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) has been used for the modulation of post-stroke cognitive impairment patients' cognitive function by altering the cortical excitability.
Recently, more challenging approaches, such as stimulation of two or more sites or use of dual modality have been studied in stroke patients. In this study, simultaneous stimulation using both facilitatory rTMS (10Hz) and anodal or cathodal tDCS (dual-mode stimulation) over bilateral dorsolateral prefrontal cortices (DLPFCs) was investigated to compare its modulatory effects with single facilitatory rTMS stimulation in post-stroke cognitive impairment patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 29
- First-ever stroke patients
- Subacute stage (less than 4 weeks)
- Who can perform the 2-back verbal and non-verbal working memory task
- K-MMSE score under 9
- Major active neurological disease or psychiatric disease
- A history of seizure
- Metallic implants in their brain
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Anodal Dual-mode stimulation High-frequency rTMS on left DLPFC+anodal tDCS on right DLPFC 10Hz of rTMS was applied over the left DLPFC for 10 minutes with simultaneous application of anodal tDCS on the right DLPFC. Each participant's 2-back verbal/nonverbal working memory task and variety cognitive function test are assessed and their resting-state fMRI data at three times: prior to stimulation (pre-stimulation), immediately after stimulation (post-stimulation) and 2 months after stimulation (f/u) are acquired. Cathodal Dual-mode stimulation High-frequency rTMS on left DLPFC+cathodal tDCS on right DLPFC 10Hz of rTMS was applied over the left DLPFC for 10 minutes with simultaneous application of cathodal tDCS on the right DLPFC. Each participant's 2-back verbal/nonverbal working memory task and variety cognitive function test are assessed and their resting-state fMRI data at three times: prior to stimulation (pre-stimulation), immediately after stimulation (post-stimulation) and 2 months after stimulation (f/u) are acquired. Single sham stimulation High-frequency rTMS on left DLPFC+sham tDCS on right DLPFC 10Hz of rTMS was applied over the left DLPFC for 10 minutes with simultaneous application of tDCS with sham mode (no stimulation) on the right DLPFC. Each participant's 2-back verbal/nonverbal working memory task and variety cognitive function test are assessed and their resting-state fMRI data at three times: prior to stimulation (pre-stimulation), immediately after stimulation (post-stimulation) and 2 months after stimulation (f/u) are acquired.
- Primary Outcome Measures
Name Time Method Accuracy of 2-back verbal working memory task Change from Pre-intervention at 2 months Accuracy (percentile) of 2-back verbal working memory task
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of