Effects of Brain Network by Simultaneous Dual-mode Stimulation in Subacute Stroke Patients
- Conditions
- Motor DisorderStroke
- Registration Number
- NCT03279640
- Lead Sponsor
- Samsung Medical Center
- Brief Summary
Repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) has been used for the modulation of stroke patients' motor function by altering the cortical excitability. Recently, more challenging approaches, such as stimulation of two or more sites or use of dual modality have been studied in stroke patients. In this study, simultaneous stimulation using both rTMS and tDCS (dual-mode stimulation) over bilateral primary motor cortices (M1s) was investigated to compare its modulatory effects with single rTMS stimulation in subacute stroke patients.
- Detailed Description
Investigators assessed each patient's motor function using the Fugl-Meyer Assessment (FMA) score and acquired their resting-state fMRI (rs-fMRI) data at two times: prior to stimulation and 2 months after stimulation. Changes in rs-fMRI network measures were investigated between groups.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 24
- First-ever stroke patients
- Subacute stage (less than 4 weeks)
- Total Fugl-Meyer Assessment (FMA) score under 84
- Major active neurological disease or psychiatric disease
- A history of seizure
- Metallic implants in their brain
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Neuroimaging Assessment Change from baseline resting-state brain network at 8 weeks after intervention Resting-state fMRI
- Secondary Outcome Measures
Name Time Method