Multicenter Study of Rasagiline in Parkinson's Disease Patients Using Levodopa and Experiencing Motor Fluctuations
- Conditions
- Parkinson's Disease
- Interventions
- Registration Number
- NCT00203034
- Lead Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
- Brief Summary
Study for patients currently using Levodopa/Carbidopa who will be assigned to receive either Rasagiline or Placebo
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 472
Men and women with idiopathic Parkinson's disease whose diagnosis is confirmed by at least two of the cardinal signs (resting tremor, bradykinesia, rigidity) being present, without any other known or suspected cause of parkinsonism.
Subjects must experience levodopa related motor fluctuations averaging at least 2.5 hours daily in the OFF state.
Subjects must be taking optimized levodopa/carbidopa or levodopa /benserazide carbidopa/levodopa therapy (based on investigator's judgment), stable for at least 14 days prior to baseline. Subjects must be receiving at least 3 daily doses of levodopa, not including a bedtime dose.
Selegiline must be discontinued for at least 90 days prior to baseline.
Subject must be age 30 or older.
Subjects must be willing and able to give informed consent.
Subjects with a clinically significant or unstable medical or surgical condition which would preclude safe and complete study participation. Such conditions may include cardiovascular, pulmonary, hepatic, renal, or metabolic diseases or malignancies as determined by medical history, physical exam, laboratory tests, chest x-ray, or ECG for Parkinson's disease [e.g., pallidotomy, thalamotomy, and deep brain stimulation (DBS)] within the 12 months preceding the Baseline visit.
Subjects who have undergone neurosurgical transplantation are excluded regardless of when the procedure(s) was performed. No programming changes are permitted in subjects who have undergone DBS.
Participation in a previous clinical trial of rasagiline. Concomitant therapy with MAO inhibitors, reserpine, methyldopa within the past three months, or treatment with an anti-emetic or neuroleptic medication with central dopamine antagonist activity with the past six months.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Experimental 1 rasagiline mesylate 0.5 mg rasagiline mesylate oral once daily Experimental 2 1.0 mg rasagiline mesylate 1.0 mg rasagiline mesylate oral once daily Placebo Placebo Placebo Comparator
- Primary Outcome Measures
Name Time Method Change from baseline in the mean total daily "OFF" time 26 weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (4)
Columbia - Presbyterian Medical Center
🇺🇸New York, New York, United States
Rush - Presbyterian St. Luke's Medical Center
🇺🇸Chicago, Illinois, United States
University of Rochester
🇺🇸Rochester, New York, United States
Baylor College of Medicine
🇺🇸Houston, Texas, United States